This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
2v60
From Proteopedia
| Line 1: | Line 1: | ||
| - | [[Image:2v60.gif|left|200px]]<br /><applet load="2v60" size=" | + | [[Image:2v60.gif|left|200px]]<br /><applet load="2v60" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="2v60, resolution 2.00Å" /> | caption="2v60, resolution 2.00Å" /> | ||
'''STRUCTURE OF HUMAN MAO B IN COMPLEX WITH THE SELECTIVE INHIBITOR 7-(3-CHLOROBENZYLOXY)-4-CARBOXALDEHYDE-COUMARIN'''<br /> | '''STRUCTURE OF HUMAN MAO B IN COMPLEX WITH THE SELECTIVE INHIBITOR 7-(3-CHLOROBENZYLOXY)-4-CARBOXALDEHYDE-COUMARIN'''<br /> | ||
| Line 7: | Line 7: | ||
==About this Structure== | ==About this Structure== | ||
| - | 2V60 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with FAD and C17 as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Amine_oxidase_(flavin-containing) Amine oxidase (flavin-containing)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.4.3.4 1.4.3.4] Known structural/functional Sites: <scene name='pdbsite=AC1:Fad Binding Site For Chain A'>AC1</scene>, <scene name='pdbsite=AC2:C17 Binding Site For Chain A'>AC2</scene>, <scene name='pdbsite=AC3:Fad Binding Site For Chain B'>AC3</scene> and <scene name='pdbsite=AC4:C17 Binding Site For Chain B'>AC4</scene>. Full crystallographic information is available from [http:// | + | 2V60 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=FAD:'>FAD</scene> and <scene name='pdbligand=C17:'>C17</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Amine_oxidase_(flavin-containing) Amine oxidase (flavin-containing)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.4.3.4 1.4.3.4] Known structural/functional Sites: <scene name='pdbsite=AC1:Fad Binding Site For Chain A'>AC1</scene>, <scene name='pdbsite=AC2:C17 Binding Site For Chain A'>AC2</scene>, <scene name='pdbsite=AC3:Fad Binding Site For Chain B'>AC3</scene> and <scene name='pdbsite=AC4:C17 Binding Site For Chain B'>AC4</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V60 OCA]. |
==Reference== | ==Reference== | ||
| Line 36: | Line 36: | ||
[[Category: transmembrane]] | [[Category: transmembrane]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 23 12:07:23 2008'' |
Revision as of 10:07, 23 January 2008
|
STRUCTURE OF HUMAN MAO B IN COMPLEX WITH THE SELECTIVE INHIBITOR 7-(3-CHLOROBENZYLOXY)-4-CARBOXALDEHYDE-COUMARIN
Overview
Structures of human monoamine oxidase B (MAO B) in complex with safinamide, and two coumarin derivatives, all sharing a common benzyloxy substituent, were determined by X-ray crystallography. These compounds competitively, inhibit MAO B with Ki values in the 0.1-0.5 muM range that are 30-700-fold, lower than those observed with MAO A. The inhibitors bind noncovalently to, MAO B, occupying both the entrance and the substrate cavities and showing, a similarly oriented benzyloxy substituent.
About this Structure
2V60 is a Single protein structure of sequence from Homo sapiens with and as ligands. Active as Amine oxidase (flavin-containing), with EC number 1.4.3.4 Known structural/functional Sites: , , and . Full crystallographic information is available from OCA.
Reference
Structures of Human Monoamine Oxidase B Complexes with Selective Noncovalent Inhibitors: Safinamide and Coumarin Analogs., Binda C, Wang J, Pisani L, Caccia C, Carotti A, Salvati P, Edmondson DE, Mattevi A, J Med Chem. 2007 Oct 4;. PMID:17915852
Page seeded by OCA on Wed Jan 23 12:07:23 2008
Categories: Amine oxidase (flavin-containing) | Homo sapiens | Single protein | Binda, C. | Caccia, C. | Carotti, A. | Edmondson, D.E. | Mattevi, A. | Pisani, L. | Salvati, P. | Wang, J. | C17 | FAD | Fad | Flavoprotein | Human mao b structure | Membrane | Mitochondrion | Neuroprotection | Oxidoreductase | Parkinson's disease | Reversible inhibitor binding | Safinamide | Transmembrane
