This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
Fibronectin
From Proteopedia
Alexander Berchansky (Talk | contribs)
(New page: Crystal Structure of Fibronectin 4-5FnI fragment 1fbr {{STRUCTURE_1fbr| PDB=1fbr | SIZE=300| SCENE= |right|CAPTION=Fibronectin 4-5FnI fragment [[1...)
Next diff →
Revision as of 08:47, 15 December 2010
Fibronectin (Fn) is a glycoprotein which binds extracellular matrix components like integrin, collagen, fibrin and others. It is a component of cell adhesion. It is a dimer of homologous monomers linked by S-S bond. Each monomer contains 3 types of modules: FnI, FnII and FnIII. Each module contains several numbered protein binding domains, i.e., 6FnI+1-2FnII is the gelatin binding domain (GBD). The images at the left and at the right correspond to one representative Fn, i.e. the crystal structure of human Fibronectin 4-5FnI fragment (1fbr).
3D Structures of Fibronectin
Fn module FnI
3m7p – hFn GBD – human 1e8b, 1e88, 1qo6 - hFn GBD – NMR 3gxe, 3ejh – hFn 8-9FnI+collagen alpha-1 1fbr - hFn 4-5FnI 2rky, 2rl0 – hFn 4-5FnI+Fn binding peptide 2rkz, 3cal - hFn 2-3FnI+Fn binding peptide 2cg6, 2cg7 - hFn 2-3FnI 2cku - hFn 2-3FnI – NMR 1o9a - hFn 1-2FnI+B3 from FNBB – NMR 2ec3 – hFn 11FnI – NMR 1qgb – hFn FnI N-terminal - NMR 2ck2 – hFn (mutant) core swapped 1j8k – hFn extra domain 2 – NMR 1fnh – hFn heparin and integrin binding domains
Fn module FnII
2fn2 – hFn 2FnII – NMR
Fn module FnIII
2h41, 2h45 – hFn 2FnIII – NMR 1oww - hFn 1FnIII – NMR 2ha1 - hFn 1-2FnIII – NMR 2crm - hFn 4FnIII – NMR 2crz - hFn 5FnIII – NMR 1fna, 1ttf, 1ttg – hFn 10FnIII 1fnf – hFn 7-10FnIII 2fnb – hFn FnIII ed-b domain – NMR 1mfn, 2mfn – Fn 9-10FnIII – mouse - NMR
