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Fibronectin
From Proteopedia
(New page: Crystal Structure of Fibronectin 4-5FnI fragment 1fbr {{STRUCTURE_1fbr| PDB=1fbr | SIZE=300| SCENE= |right|CAPTION=Fibronectin 4-5FnI fragment [[1...) |
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[[Image:1fbr.png|left|200px|thumb|Crystal Structure of Fibronectin 4-5FnI fragment [[1fbr]]]] | [[Image:1fbr.png|left|200px|thumb|Crystal Structure of Fibronectin 4-5FnI fragment [[1fbr]]]] | ||
| - | {{STRUCTURE_1fbr| PDB=1fbr | SIZE=300| SCENE= |right|CAPTION=Fibronectin 4-5FnI fragment [[1fbr]] }} | + | {{STRUCTURE_1fbr| PDB=1fbr | SIZE=300| SCENE=Fibronectin/Cv/1 |right|CAPTION=Fibronectin 4-5FnI fragment [[1fbr]] }} |
[[Fibronectin]] (Fn) is a glycoprotein which binds extracellular matrix components like integrin, collagen, fibrin and others. It is a component of cell adhesion. It is a dimer of homologous monomers linked by S-S bond. Each monomer contains 3 types of modules: FnI, FnII and FnIII. Each module contains several numbered protein binding domains, i.e., 6FnI+1-2FnII is the gelatin binding domain (GBD). The images at the left and at the right correspond to one representative Fn, ''i.e.'' the crystal structure of human Fibronectin 4-5FnI fragment ([[1fbr]]). | [[Fibronectin]] (Fn) is a glycoprotein which binds extracellular matrix components like integrin, collagen, fibrin and others. It is a component of cell adhesion. It is a dimer of homologous monomers linked by S-S bond. Each monomer contains 3 types of modules: FnI, FnII and FnIII. Each module contains several numbered protein binding domains, i.e., 6FnI+1-2FnII is the gelatin binding domain (GBD). The images at the left and at the right correspond to one representative Fn, ''i.e.'' the crystal structure of human Fibronectin 4-5FnI fragment ([[1fbr]]). | ||
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=== Fn module FnI === | === Fn module FnI === | ||
| - | [[3m7p]] – hFn GBD – human | + | [[3m7p]] – hFn GBD – human<br /> |
| - | 1e8b, 1e88, 1qo6 - hFn GBD – NMR | + | [[1e8b]], [[1e88]], [[1qo6]] - hFn GBD – NMR<br /> |
| - | 3gxe, 3ejh – hFn 8-9FnI+collagen alpha-1 | + | [[3gxe]], [[3ejh]] – hFn 8-9FnI+collagen alpha-1<br /> |
| - | 1fbr - hFn 4-5FnI | + | [[1fbr]] - hFn 4-5FnI<br /> |
| - | 2rky, 2rl0 – hFn 4-5FnI+Fn binding peptide | + | [[2rky]], [[2rl0]] – hFn 4-5FnI+Fn binding peptide<br /> |
| - | 2rkz, 3cal - hFn 2-3FnI+Fn binding peptide | + | [[2rkz]], [[3cal]] - hFn 2-3FnI+Fn binding peptide<br /> |
| - | 2cg6, 2cg7 - hFn 2-3FnI | + | [[2cg6]], [[2cg7]] - hFn 2-3FnI<br /> |
| - | 2cku - hFn 2-3FnI – NMR | + | [[2cku]] - hFn 2-3FnI – NMR<br /> |
| - | 1o9a - hFn 1-2FnI+B3 from FNBB – NMR | + | [[1o9a]] - hFn 1-2FnI+B3 from FNBB – NMR<br /> |
| - | 2ec3 – hFn 11FnI – NMR | + | [[2ec3]] – hFn 11FnI – NMR<br /> |
| - | 1qgb – hFn FnI N-terminal - NMR | + | [[1qgb]] – hFn FnI N-terminal - NMR<br /> |
| - | 2ck2 – hFn (mutant) core swapped | + | [[2ck2]] – hFn (mutant) core swapped<br /> |
| - | 1j8k – hFn extra domain 2 – NMR | + | [[1j8k]] – hFn extra domain 2 – NMR<br /> |
| - | 1fnh – hFn heparin and integrin binding domains | + | [[1fnh]] – hFn heparin and integrin binding domains |
=== Fn module FnII === | === Fn module FnII === | ||
| - | 2fn2 – hFn 2FnII – NMR | + | [[2fn2]] – hFn 2FnII – NMR |
=== Fn module FnIII === | === Fn module FnIII === | ||
| - | 2h41, 2h45 – hFn 2FnIII – NMR | + | [[2h41]], [[2h45]] – hFn 2FnIII – NMR<br /> |
| - | 1oww - hFn 1FnIII – NMR | + | [[1oww]] - hFn 1FnIII – NMR<br /> |
| - | 2ha1 - hFn 1-2FnIII – NMR | + | [[2ha1]] - hFn 1-2FnIII – NMR<br /> |
| - | 2crm - hFn 4FnIII – NMR | + | [[2crm]] - hFn 4FnIII – NMR<br /> |
| - | 2crz - hFn 5FnIII – NMR | + | [[2crz]] - hFn 5FnIII – NMR<br /> |
| - | 1fna, 1ttf, 1ttg – hFn 10FnIII | + | [[1fna]], [[1ttf]], [[1ttg]] – hFn 10FnIII<br /> |
| - | 1fnf – hFn 7-10FnIII | + | [[1fnf]] – hFn 7-10FnIII<br /> |
| - | 2fnb – hFn FnIII ed-b domain – NMR | + | [[2fnb]] – hFn FnIII ed-b domain – NMR<br /> |
| - | 1mfn, 2mfn – Fn 9-10FnIII – mouse - NMR | + | [[1mfn]], [[2mfn]] – Fn 9-10FnIII – mouse - NMR |
Revision as of 08:53, 15 December 2010
Fibronectin (Fn) is a glycoprotein which binds extracellular matrix components like integrin, collagen, fibrin and others. It is a component of cell adhesion. It is a dimer of homologous monomers linked by S-S bond. Each monomer contains 3 types of modules: FnI, FnII and FnIII. Each module contains several numbered protein binding domains, i.e., 6FnI+1-2FnII is the gelatin binding domain (GBD). The images at the left and at the right correspond to one representative Fn, i.e. the crystal structure of human Fibronectin 4-5FnI fragment (1fbr).
3D Structures of Fibronectin
Fn module FnI
3m7p – hFn GBD – human
1e8b, 1e88, 1qo6 - hFn GBD – NMR
3gxe, 3ejh – hFn 8-9FnI+collagen alpha-1
1fbr - hFn 4-5FnI
2rky, 2rl0 – hFn 4-5FnI+Fn binding peptide
2rkz, 3cal - hFn 2-3FnI+Fn binding peptide
2cg6, 2cg7 - hFn 2-3FnI
2cku - hFn 2-3FnI – NMR
1o9a - hFn 1-2FnI+B3 from FNBB – NMR
2ec3 – hFn 11FnI – NMR
1qgb – hFn FnI N-terminal - NMR
2ck2 – hFn (mutant) core swapped
1j8k – hFn extra domain 2 – NMR
1fnh – hFn heparin and integrin binding domains
Fn module FnII
2fn2 – hFn 2FnII – NMR
Fn module FnIII
2h41, 2h45 – hFn 2FnIII – NMR
1oww - hFn 1FnIII – NMR
2ha1 - hFn 1-2FnIII – NMR
2crm - hFn 4FnIII – NMR
2crz - hFn 5FnIII – NMR
1fna, 1ttf, 1ttg – hFn 10FnIII
1fnf – hFn 7-10FnIII
2fnb – hFn FnIII ed-b domain – NMR
1mfn, 2mfn – Fn 9-10FnIII – mouse - NMR
