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Heat Shock Proteins

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=== Hsp90 – 4 domains: N-terminus (NTD); linker; middle (MD); C-terminus (CT) ===
=== Hsp90 – 4 domains: N-terminus (NTD); linker; middle (MD); C-terminus (CT) ===
-
[[3k97]], [[3hek]] – hHsp90 NTD+pyrrolidin derivative – human
+
[[3k97]], [[3hek]] – hHsp90 NTD+pyrrolidin derivative – human<br />
-
[[3k98]], [[3k99]] - hHsp90 NTD+indole derivative
+
[[3k98]], [[3k99]] - hHsp90 NTD+indole derivative<br />
-
[[3ied]] - Hsp90 NTD+AMPPN – Plasmodium falciparum
+
[[3ied]] - Hsp90 NTD+AMPPN – ''Plasmodium falciparum''<br />
-
[[2wi1]], [[2wi2]], [[2wi3]], [[2wi4]], [[2wi5]], [[2wi6]], [[2wi7]] - hHsp90 NTD+2-amino thienopyrimidine
+
[[2wi1]], [[2wi2]], [[2wi3]], [[2wi4]], [[2wi5]], [[2wi6]], [[2wi7]] - hHsp90 NTD+2-amino thienopyrimidine<br />
-
[[3hhu]] - hHsp90 NTD+ carbamic acid derivative
+
[[3hhu]] - hHsp90 NTD+ carbamic acid derivative<br />
-
[[3ft8]], [[3ft5]] - hHsp90 NTD+quinazoline derivative
+
[[3ft8]], [[3ft5]] - hHsp90 NTD+quinazoline derivative<br />
-
[[2k5b]] - hHsp90 NTD+Cdc37 – NMR - docking
+
[[2k5b]] - hHsp90 NTD+Cdc37 – NMR - docking<br />
-
[[3eko]], [[3ekr]] - hHsp90 NTD+dihydroxyphenyl amide
+
[[3eko]], [[3ekr]] - hHsp90 NTD+dihydroxyphenyl amide<br />
-
[[2jki]] - Hsp90 NTD+SGT1 domain protein –barley
+
[[2jki]] - Hsp90 NTD+SGT1 domain protein –barley<br />
-
[[2jjc]] - hHsp90 NTD+pyrimidine-2-amine
+
[[2jjc]] - hHsp90 NTD+pyrimidine-2-amine<br />
-
[[3bm9]], [[3bmy]] - hHsp90 NTD+benzisoxazole
+
[[3bm9]], [[3bmy]] - hHsp90 NTD+benzisoxazole<br />
-
[[2of6]] - hHsp90 NTD+triazine derivative
+
[[2of6]] - hHsp90 NTD+triazine derivative<br />
-
[[2qfo]] - hHsp90 NTD+pyrimidine derivative
+
[[2qfo]] - hHsp90 NTD+pyrimidine derivative<br />
-
[[1uy6]], [[1uy7]], [[1uy8]], [[1uy9]], [[1uyc]], [[1uyd]], [[1uye]], [[1uyf]], [[1uyg]], [[1uyh]], [[1uyi]], [[1uyk]], [[1uyl]] - hHsp90 NTD+purine derivative
+
[[1uy6]], [[1uy7]], [[1uy8]], [[1uy9]], [[1uyc]], [[1uyd]], [[1uye]], [[1uyf]], [[1uyg]], [[1uyh]], [[1uyi]], [[1uyk]], [[1uyl]] - hHsp90 NTD+purine derivative<br />
-
[[2qg0]], [[2bz5]] - hHsp90 NTD+sulfonamide derivative
+
[[2qg0]], [[2bz5]] - hHsp90 NTD+sulfonamide derivative<br />
-
[[2qg2]], [[2cvi]], [[2cvj]], [[2uwd]] - hHsp90 NTD+oxazol derivative
+
[[2qg2]], [[2cvi]], [[2cvj]], [[2uwd]] - hHsp90 NTD+oxazol derivative<br />
-
[[3d0b]] - hHsp90 NTD+benzamide derivative
+
[[3d0b]] - hHsp90 NTD+benzamide derivative<br />
-
[[2fwy]], [[2fwz]], [[2h55]], [[1uym]] - hHsp90 NTD+PU inhibitor
+
[[2fwy]], [[2fwz]], [[2h55]], [[1uym]] - hHsp90 NTD+PU inhibitor<br />
[[2ccs]], [[2cct]], [[2ccu]], [[2cdd]], [[2byh]], [[2byi]], [[2bsm]], [[2bt0]], [[1yc3]] - hHsp90 NTD+pyrazol derivative
[[2ccs]], [[2cct]], [[2ccu]], [[2cdd]], [[2byh]], [[2byi]], [[2bsm]], [[2bt0]], [[1yc3]] - hHsp90 NTD+pyrazol derivative
-
[[2brc]], [[2bre]], [[1am1]] - ScHsp90 NTD+pyrazol derivative
+
[[2brc]], [[2bre]], [[1am1]] - ScHsp90 NTD+pyrazol derivative<br />
-
[[1amw]] - ScHsp90 NTD+ADP
+
[[1amw]] - ScHsp90 NTD+ADP<br />
-
[[1ah6]], [[1ah8]] - ScHsp90 NTD
+
[[1ah6]], [[1ah8]] - ScHsp90 NTD<br />
-
[[1osf]], [[1yer]], [[1yes]], [[1yet]] - hHsp90 NTD+geldamycin
+
[[1osf]], [[1yer]], [[1yes]], [[1yet]] - hHsp90 NTD+geldamycin <br />
-
[[1bgq]] – yHsp90+radicicol - yeast
+
[[1bgq]] – yHsp90+radicicol - yeast<br />
-
[[1byq]] - hHsp90 NTD+ATP-Mg
+
[[1byq]] - hHsp90 NTD+ATP-Mg<br />
[[1a4h]] – yHsp90+ geldamycin
[[1a4h]] – yHsp90+ geldamycin
Line 90: Line 90:
=== Hsp82 is the yeast equivalent of Hsp90 in mammals ===
=== Hsp82 is the yeast equivalent of Hsp90 in mammals ===
-
1ah6, 1ah8 – yHsp82 NTD
+
[[1ah6]], [[1ah8]] – yHsp82 NTD<br />
-
2wep – yHsp82 NTD (mutant)+ADP
+
[[2wep]] – yHsp82 NTD (mutant)+ADP<br />
-
2akp - yHsp82 NTD (mutant)
+
[[2akp]] - yHsp82 NTD (mutant)<br />
-
1weq, 3c11 - yHsp82 NTD (mutant)+ geldamycin
+
[[1weq]], [[3c11]] - yHsp82 NTD (mutant)+ geldamycin<br />
-
2wer - yHsp82 NTD (mutant)+radicicol
+
[[2wer]] - yHsp82 NTD (mutant)+radicicol<br />
-
1bgq - yHsp82 NTD +radicicol
+
[[1bgq]] - yHsp82 NTD +radicicol<br />
-
2iws, 2iwu, 2iwx, 2cgf - yHsp82 NTD +radicicol analogues
+
[[2iws]], [[2iwu]], [[2iwx]], [[2cgf]] - yHsp82 NTD +radicicol analogues<br />
-
2vw5, 2vwc - yHsp82 NTD +7-o-carbamoylpremacbecin
+
[[2vw5]], [[2vwc]] - yHsp82 NTD +7-o-carbamoylpremacbecin<br />
-
3c0e - yHsp82 NTD (mutant)
+
[[3c0e]] - yHsp82 NTD (mutant)<br />
-
2fxs - yHsp82 NTD +radamide
+
[[2fxs]] - yHsp82 NTD +radamide<br />
-
1zw9 - yHsp82 NTD + adenine derivative
+
[[1zw9]] - yHsp82 NTD + adenine derivative<br />
-
1zwh - yHsp82 NTD + radester amine
+
[[1zwh]] - yHsp82 NTD + radester amine<br />
-
2brc, 2bre - yHsp82 NTD+pyrazol derivative
+
[[2brc]], [[2bre]] - yHsp82 NTD+pyrazol derivative<br />
-
2cg9 – yHsp82+co-chaperone SBA1
+
[[2cg9]] – yHsp82+co-chaperone SBA1<br />
-
2cge - yHsp82 MD+CT+co-chaperone SBA1
+
[[2cge]] - yHsp82 MD+CT+co-chaperone SBA1<br />
-
1hk7 - yHsp82 MD
+
[[1hk7]] - yHsp82 MD<br />
-
1usu, 1usv - yHsp82 MD+co-chaperone AHA1
+
[[1usu]], [[1usv]] - yHsp82 MD+co-chaperone AHA1<br />
-
1us7 - yHsp82 NTD+co-chaperone cdc37
+
[[1us7]] - yHsp82 NTD+co-chaperone cdc37
=== Hsp100 are named ClpA or ClpB ===
=== Hsp100 are named ClpA or ClpB ===
-
1r6b, 1ksf – EcClpA (mutant) - Escherichia coli
+
[[1r6b]], [[1ksf]] – EcClpA (mutant) - ''Escherichia coli''<br />
-
1khy – EcClpB NTD
+
[[1khy]] – EcClpB NTD <br />
-
1jbk – EcClpB NBD
+
[[1jbk]] – EcClpB NBD<br />
-
1k6k - EcClpA NTD
+
[[1k6k]] - EcClpA NTD
=== Hsp110 in mammals is named Sse1, Sse2 in yeast ===
=== Hsp110 in mammals is named Sse1, Sse2 in yeast ===
-
3d2e, 3d2f, 3c7n – Sse1+Hsp70 – yeast
+
[[3d2e]], [[3d2f]], [[3c7n]] – Sse1+Hsp70 – yeast<br />
-
2qxl – Sse1 - yeast
+
[[2qxl]] – Sse1 - yeast

Revision as of 09:40, 15 December 2010

Image:3los.jpg
Crystal Structure of Hsp60 3los

Template:STRUCTURE 3los

Heat Shock Proteins (Hsp). The Hsp are proteins which are expressed when cells are exposed to stresses like heat. Hsp60, Hsp70, Hsp90 etc. are named according to their molecular weights. Their function is to provide protection from stress. The images at the left and at the right correspond to one representative Hsp, i.e. the crystal structure of Hsp60 from Methanococcus maripaludis (3los).

Contents

3D Structures of Heat Shock Proteins

Hsp60 - the large subunit of the chaperonin molecule GroEL

3los – MmHsp60 - GroEL – Methanococcus maripaludis – closed state
3iyf - MmHsp60 - GroEL – open state
3e76 – EcHsp60 – GroEL+Tl ion – Escherichia coli
2nwc, 1oel, 1grl - EcHsp60 – GroEL
2eu1 - EcHsp60 (mutant) – GroEL
2cgt - EcHsp60 – GroEL+ADP+capsid assembly protein Gp31
2c7c, 2c7d - EcHsp60 – GroEL+GroES – cryo EM
1we3, 1wf4 - TtHsp60 – GroEL+GroES – Thermus thermophilus
1gr5 - EcHsp60 – GroEL – cryo EM
1gru - EcHsp60 – GroEL+ATP+GroES+ADP – cryo EM
1dkd - EcHsp60 – GroEL apical (top) domain (146 amino acids)+12-mer peptide
1dk7, 1jon - EcHsp60 – GroEL apical domain
1srv - TtHsp60 – GroEL apical domain
1ass, 1asx - Hsp60 – GroEL apical domain – Thermoplasma acidophilum
1kid - EcHsp60 (mutant) – GroEL apical domain


Hsp70 – 3 domains: N-terminus ATPase hydrolyzes ATP to ADP (NBD); hydrophobic amino acid binding domain (sub): C-terminus lid domain (lid).

3a8y – hHsp70 NBD+BAG domain regulator protein – human
3fzf - hHsp70 NBD+BAG domain regulator protein+ATP
3fzh, 3fzm - hHsp70 NBD+BAG domain regulator protein+ adenosine derivative
3fzk, 3fzl - hHsp70 NBD+BAG domain regulator protein+ purine derivative
3cqx - Hsp70 NBD+BAG domain regulator protein – mouse
3lof – hHsp70 lid
2p32 - CeHsp70 lid
3l6q - CpHsp70 NBD – Cryptosporidium parvum
3kvg - CpHsp70 NBD+AMPPNP
3l4i - CpHsp70 NBD+ADP+P
3jxu, 3i33, 3gdq, 3fe1 - hHsp70 NBD+ADP+P
3iuc - hHsp70 NBD+ADP
2e88, 1s3x, 1hjo - hHsp70 NBD
2e8a - hHsp70 NBD+AMPPNP
2qw9 – cHsp70 NBD – cow
2bup - cHsp70 NBD (mutant)
2qwl, 2qwm - cHsp70 NBD+ADP
2qwn, 2qwo, 2qwp, 2qwq, 2qwr - cHsp70 NBD (mutant)+ auxilin protein
2kho – EcHsp70 – Escherichia coli – NMR
3gl1 - ScHsp70 NBD – Saccharomyces cerevisiae
3dpo – EcHsp70 sub+12-mer peptide
3dpp, 3dpq – EcHsp70 sub+20-mer peptide
3dob, 3dqg, 2op6 - CeHsp70 sub – Caenoharbditis elegans
2d2e, 3d2f – ScHsp70 NBD+SSE1(Hsp110)
2v7z – rHsp70 NBD+sub – rat
7hsc, 1ckr - rHsp70 sub - NMR


Hsp90 – 4 domains: N-terminus (NTD); linker; middle (MD); C-terminus (CT)

3k97, 3hek – hHsp90 NTD+pyrrolidin derivative – human
3k98, 3k99 - hHsp90 NTD+indole derivative
3ied - Hsp90 NTD+AMPPN – Plasmodium falciparum
2wi1, 2wi2, 2wi3, 2wi4, 2wi5, 2wi6, 2wi7 - hHsp90 NTD+2-amino thienopyrimidine
3hhu - hHsp90 NTD+ carbamic acid derivative
3ft8, 3ft5 - hHsp90 NTD+quinazoline derivative
2k5b - hHsp90 NTD+Cdc37 – NMR - docking
3eko, 3ekr - hHsp90 NTD+dihydroxyphenyl amide
2jki - Hsp90 NTD+SGT1 domain protein –barley
2jjc - hHsp90 NTD+pyrimidine-2-amine
3bm9, 3bmy - hHsp90 NTD+benzisoxazole
2of6 - hHsp90 NTD+triazine derivative
2qfo - hHsp90 NTD+pyrimidine derivative
1uy6, 1uy7, 1uy8, 1uy9, 1uyc, 1uyd, 1uye, 1uyf, 1uyg, 1uyh, 1uyi, 1uyk, 1uyl - hHsp90 NTD+purine derivative
2qg0, 2bz5 - hHsp90 NTD+sulfonamide derivative
2qg2, 2cvi, 2cvj, 2uwd - hHsp90 NTD+oxazol derivative
3d0b - hHsp90 NTD+benzamide derivative
2fwy, 2fwz, 2h55, 1uym - hHsp90 NTD+PU inhibitor
2ccs, 2cct, 2ccu, 2cdd, 2byh, 2byi, 2bsm, 2bt0, 1yc3 - hHsp90 NTD+pyrazol derivative 2brc, 2bre, 1am1 - ScHsp90 NTD+pyrazol derivative
1amw - ScHsp90 NTD+ADP
1ah6, 1ah8 - ScHsp90 NTD
1osf, 1yer, 1yes, 1yet - hHsp90 NTD+geldamycin
1bgq – yHsp90+radicicol - yeast
1byq - hHsp90 NTD+ATP-Mg
1a4h – yHsp90+ geldamycin


Hsp82 is the yeast equivalent of Hsp90 in mammals

1ah6, 1ah8 – yHsp82 NTD
2wep – yHsp82 NTD (mutant)+ADP
2akp - yHsp82 NTD (mutant)
1weq, 3c11 - yHsp82 NTD (mutant)+ geldamycin
2wer - yHsp82 NTD (mutant)+radicicol
1bgq - yHsp82 NTD +radicicol
2iws, 2iwu, 2iwx, 2cgf - yHsp82 NTD +radicicol analogues
2vw5, 2vwc - yHsp82 NTD +7-o-carbamoylpremacbecin
3c0e - yHsp82 NTD (mutant)
2fxs - yHsp82 NTD +radamide
1zw9 - yHsp82 NTD + adenine derivative
1zwh - yHsp82 NTD + radester amine
2brc, 2bre - yHsp82 NTD+pyrazol derivative
2cg9 – yHsp82+co-chaperone SBA1
2cge - yHsp82 MD+CT+co-chaperone SBA1
1hk7 - yHsp82 MD
1usu, 1usv - yHsp82 MD+co-chaperone AHA1
1us7 - yHsp82 NTD+co-chaperone cdc37


Hsp100 are named ClpA or ClpB

1r6b, 1ksf – EcClpA (mutant) - Escherichia coli
1khy – EcClpB NTD
1jbk – EcClpB NBD
1k6k - EcClpA NTD


Hsp110 in mammals is named Sse1, Sse2 in yeast

3d2e, 3d2f, 3c7n – Sse1+Hsp70 – yeast
2qxl – Sse1 - yeast

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Jaime Prilusky

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