Talin

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(New page: Crystal Structure of Talin 2x0c {{STRUCTURE_2x0c| PDB=2x0c | SIZE=300| SCENE= |right|CAPTION=Talin 2x0c }} Talin is involved in cell-cell con...)
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[[Image:2x0c.png|left|200px|thumb|Crystal Structure of Talin [[2x0c]]]]
[[Image:2x0c.png|left|200px|thumb|Crystal Structure of Talin [[2x0c]]]]
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{{STRUCTURE_2x0c| PDB=2x0c | SIZE=300| SCENE= |right|CAPTION=Talin [[2x0c]] }}
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{{STRUCTURE_2x0c| PDB=2x0c | SIZE=300| SCENE=Talin/Cv/1 |right|CAPTION=Talin [[2x0c]] }}
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Talin is involved in cell-cell contacts. It links integrins to actin. It contains a C-terminal rod domain with integrin binding sites (IBS) and actin binding sites (ABS) and N-terminal FERM domain with subdomains F0-F3. The F3 subdomains interacts with integrin. Talin contains 3 vinculin binding sites VBS1-VBS3.
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[[Talin]] is involved in cell-cell contacts. It links integrins to actin. It contains a C-terminal rod domain with integrin binding sites (IBS) and actin binding sites (ABS) and N-terminal FERM domain with subdomains F0-F3. The F3 subdomains interacts with integrin. Talin contains 3 [[Vinculin]] binding sites VBS1-VBS3. The images at the left and at the right correspond to one representative Talin, ''i.e.'' the crystal structure of mouse Talin rod ([[2x0c]]).
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Talin subdomains
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{{TOC limit|limit=2}}
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2x0c, 2kbb, 3dyj, 1sj7, 1sj8 – mTal rod – mouse
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== 3D Structures of Talin ==
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2kma – mTal F0F1 – NMR
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2kc1 - mTal F0 – NMR
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2kc2 - mTal F1 – NMR
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2hrj - cTal F2 – NMR
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1mix – cTal F2F3
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2kgx – mTal F3+mTal fragment – NMR
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Integrin binding sites
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=== Talin subdomains ===
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2jsw, 2qdq – mTal IBS – NMR
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[[2x0c]], [[2kbb]], [[3dyj]], [[1sj7]], [[1sj8]] – mTal rod – mouse<br />
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3g9w – mTal F2F3+integrin tail
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[[2kma]] – mTal F0F1 – NMR<br />
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1miz, 1mk7, 1mk9 - hTal+integrin tail
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[[2kc1]] - mTal F0 – NMR<br />
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2h7d, 2h7e - cTal FERM F3+integrlin fragment – NMR
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[[2kc2]] - mTal F1 – NMR<br />
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3fyq – Tal rod IBS2 – Drosophila melanogaster
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[[2hrj]] - cTal F2 – NMR <br />
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[[1mix]] – cTal F2F3<br />
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[[2kgx]] – mTal F3+mTal fragment – NMR
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Vinculin binding sites
 
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2kvp, 2b0h – mTal VBS3 – NMR
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=== Integrin binding sites ===
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1xwj, 1zvz, 1zw2, 1zw3 - cTal VBS3+ vinculin head – chicken
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1u6h - cTal VBS2+ vinculin head
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1t01 - cTal VBS1+ vinculin head
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1syq - hTal VBS1+ vinculin head – human
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1rkc - hTal VBS3+ vinculin head
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1u89 - mTal VBS2 – NMR
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PIP kinase binding sites
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[[2jsw]], [[2qdq]] – mTal IBS – NMR<br />
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[[3g9w]] – mTal F2F3+integrin tail<br />
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[[1miz]], [[1mk7]], [[1mk9]] - hTal+integrin tail<br />
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[[2h7d]], [[2h7e]] - cTal FERM F3+integrlin fragment – NMR <br />
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[[3fyq]] – Tal rod IBS2 – ''Drosophila melanogaster''
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1y19 - mTal F2F3+ PIP kinase C-terminal
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=== Vinculin binding sites ===
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2g35 - mTal F3+PIP kinase peptide – NMR
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Layilin binding sites
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[[2kvp]], [[2b0h]] – mTal VBS3 – NMR<br />
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[[1xwj]], [[1zvz]], [[1zw2]], [[1zw3]] - cTal VBS3+ vinculin head – chicken<br />
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[[1u6h]] - cTal VBS2+ vinculin head<br />
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[[1t01]] - cTal VBS1+ vinculin head<br />
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[[1syq]] - hTal VBS1+ vinculin head – human<br />
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[[1rkc]] - hTal VBS3+ vinculin head<br />
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[[1u89]] - mTal VBS2 – NMR<br />
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2k00 - cTal F3+layilin fragment – NMR
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=== PIP kinase binding sites ===
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[[1y19]] - mTal F2F3+ PIP kinase C-terminal<br />
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[[2g35]] - mTal F3+PIP kinase peptide – NMR
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=== Layilin binding sites ===
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[[2k00]] - cTal F3+layilin fragment – NMR

Revision as of 09:47, 16 December 2010

Image:2x0c.png
Crystal Structure of Talin 2x0c

Template:STRUCTURE 2x0c

Talin is involved in cell-cell contacts. It links integrins to actin. It contains a C-terminal rod domain with integrin binding sites (IBS) and actin binding sites (ABS) and N-terminal FERM domain with subdomains F0-F3. The F3 subdomains interacts with integrin. Talin contains 3 Vinculin binding sites VBS1-VBS3. The images at the left and at the right correspond to one representative Talin, i.e. the crystal structure of mouse Talin rod (2x0c).

Contents

3D Structures of Talin

Talin subdomains

2x0c, 2kbb, 3dyj, 1sj7, 1sj8 – mTal rod – mouse
2kma – mTal F0F1 – NMR
2kc1 - mTal F0 – NMR
2kc2 - mTal F1 – NMR
2hrj - cTal F2 – NMR
1mix – cTal F2F3
2kgx – mTal F3+mTal fragment – NMR


Integrin binding sites

2jsw, 2qdq – mTal IBS – NMR
3g9w – mTal F2F3+integrin tail
1miz, 1mk7, 1mk9 - hTal+integrin tail
2h7d, 2h7e - cTal FERM F3+integrlin fragment – NMR
3fyq – Tal rod IBS2 – Drosophila melanogaster

Vinculin binding sites

2kvp, 2b0h – mTal VBS3 – NMR
1xwj, 1zvz, 1zw2, 1zw3 - cTal VBS3+ vinculin head – chicken
1u6h - cTal VBS2+ vinculin head
1t01 - cTal VBS1+ vinculin head
1syq - hTal VBS1+ vinculin head – human
1rkc - hTal VBS3+ vinculin head
1u89 - mTal VBS2 – NMR


PIP kinase binding sites

1y19 - mTal F2F3+ PIP kinase C-terminal
2g35 - mTal F3+PIP kinase peptide – NMR


Layilin binding sites

2k00 - cTal F3+layilin fragment – NMR

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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