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Fibrinogen

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cFba + cFbb + cFbg:
cFba + cFbb + cFbg:
[[1jy3]], [[1deq]]
[[1jy3]], [[1deq]]
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cFba+cFbb+cFbg proteolytic fragment: [[1jy2]]
==== Sea lamprey ====
==== Sea lamprey ====
Fba + Fbb + Fbg + peptide ligand:
Fba + Fbb + Fbg + peptide ligand:

Revision as of 12:26, 20 December 2010

Image:3hus2.jpg
Crystal Structure of Fibrinogen with peptide ligand, 3hus

Crystal structure of fibrinogen fragment D with the peptide ligand Gly-Pro-Arg-Pro-amide, 3hus

Drag the structure with the mouse to rotate

Fibrinogen is a glycoprotein found in the blood that is converted into fibrin during blood coagulation. Fibrinogen is cleaved by another protein, thrombin, exposing knobs A and B to form fibrin. [1] It is this fibrin that forms clots to prevent excessive bleeding from wounds sustained. Clotting factors, like factor XIII, are often linked to fibrin. [2]

Contents


3D Structure of Fibrinogen

Fibrinogen is composed of 2 copies each of 3 non-identical chains alpha, beta, gamma (, , ).

Fibrinogen alpha+beta+gamma chains

Human

hFba + hFbb + hFbg: 1re4, 1rf0, 1n8e, 1lt9
hFba + hFbb + hFbg + knobs A & B: 3ghg, 2q9i, 2z4e
hFba + hFbb + hFbg + peptide ligand: 3hus, 3h32, 3e1i, 3bvh, 2hlo, 2hod, 2hpc, 2oyh, 2oyi, 2h43, 2ffd, 1re3, 1rf1, 1n86, 1ltj
hFba + hFbb + hFbg + thrombin + PPACK thrombin inhibitor: 2a45

Cow

cFba + cFbb + cFbg: 1jy3, 1deq cFba+cFbb+cFbg proteolytic fragment: 1jy2

Sea lamprey

Fba + Fbb + Fbg + peptide ligand: 1n73, 1lwu

Hen

heFba + heFbb + heFbg: 1ei3
heFba + heFbb + heFbg + peptide ligand: 1m1j

Fibrinogen alpha chain

cFba: 2baf
cFba – NMR: 2jor
hFba EC domain: 1fzd

Fibrinogen beta chain

hFb fragment D: 1fze, 1fza, 1fzb
hFb fragment double-D + peptide ligand: 1fzf, 1fzg

Fibrinogen gamma chain

hFbg: 1fic, 1fid
hFbg + Ca: 1fib
hFbg + peptide ligand: 2fib, 3fib
hFbg + SaClumping Factor A – Staphylococcus aureus: 2vr3
hFbg + Integrin alpha IIB + Integrin beta-3 + Monoclonal antibody heavy and light chains: 2vdo, 2vdp, 2vdq, 2vdr

References

  1. ↑ Betts L, Merenbloom BK, Lord ST. The structure of fibrinogen fragment D with the 'A' knob peptide GPRVVE. J Thromb Haemost. 2006 May;4(5):1139-41. PMID:16689770 doi:10.1111/j.1538-7836.2006.01902.x
  2. ↑ Muszbek L, Bagoly Z, Bereczky Z, Katona E. The involvement of blood coagulation factor XIII in fibrinolysis and thrombosis. Cardiovasc Hematol Agents Med Chem. 2008 Jul;6(3):190-205. PMID:18673233

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, David Canner, Mark Hoelzer, Alexander Berchansky, Angel Herraez

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