3mkm

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[[Category: Pyrimidine nucleoside hydrolase]]
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Revision as of 06:12, 22 December 2010

Template:STRUCTURE 3mkm

Crystal structure of the E. coli pyrimidine nucleoside hydrolase YeiK (Apo-form)

Template:ABSTRACT PUBMED 21082835

About this Structure

3MKM is a 4 chains structure with sequences from Escherichia coli. Full crystallographic information is available from OCA.

Reference

  • Fornili A, Giabbai B, Garau G, Degano M. Energy Landscapes Associated with Macromolecular Conformational Changes from Endpoint Structures. J Am Chem Soc. 2010 Nov 17. PMID:21082835 doi:10.1021/ja107640u
  • Giabbai B, Degano M. Crystal structure to 1.7 a of the Escherichia coli pyrimidine nucleoside hydrolase YeiK, a novel candidate for cancer gene therapy. Structure. 2004 May;12(5):739-49. PMID:15130467 doi:http://dx.doi.org/10.1016/j.str.2004.03.018
  • Muzzolini L, Versees W, Tornaghi P, Van Holsbeke E, Steyaert J, Degano M. New insights into the mechanism of nucleoside hydrolases from the crystal structure of the Escherichia coli YbeK protein bound to the reaction product. Biochemistry. 2006 Jan 24;45(3):773-82. PMID:16411753 doi:10.1021/bi0511991
  • Degano M, Almo SC, Sacchettini JC, Schramm VL. Trypanosomal nucleoside hydrolase. A novel mechanism from the structure with a transition-state inhibitor. Biochemistry. 1998 May 5;37(18):6277-85. PMID:9572842 doi:http://dx.doi.org/10.1021/bi973012e

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