2qzr
From Proteopedia
(New page: 200px<br /><applet load="2qzr" size="450" color="white" frame="true" align="right" spinBox="true" caption="2qzr, resolution 1.95Å" /> '''tRNA-Guanine Transgl...) |
|||
| Line 1: | Line 1: | ||
| - | [[Image:2qzr.jpg|left|200px]]<br /><applet load="2qzr" size=" | + | [[Image:2qzr.jpg|left|200px]]<br /><applet load="2qzr" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="2qzr, resolution 1.95Å" /> | caption="2qzr, resolution 1.95Å" /> | ||
'''tRNA-Guanine Transglycosylase(TGT) in Complex with 6-amino-2-[(1-naphthylmethyl)amino]-3,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one'''<br /> | '''tRNA-Guanine Transglycosylase(TGT) in Complex with 6-amino-2-[(1-naphthylmethyl)amino]-3,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one'''<br /> | ||
==About this Structure== | ==About this Structure== | ||
| - | 2QZR is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Zymomonas_mobilis Zymomonas mobilis] with ZN, S79 and GOL as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Queuine_tRNA-ribosyltransferase Queuine tRNA-ribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.29 2.4.2.29] Full crystallographic information is available from [http:// | + | 2QZR is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Zymomonas_mobilis Zymomonas mobilis] with <scene name='pdbligand=ZN:'>ZN</scene>, <scene name='pdbligand=S79:'>S79</scene> and <scene name='pdbligand=GOL:'>GOL</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Queuine_tRNA-ribosyltransferase Queuine tRNA-ribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.29 2.4.2.29] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QZR OCA]. |
==Reference== | ==Reference== | ||
| - | Potent | + | Potent inhibitors of tRNA-guanine transglycosylase, an enzyme linked to the pathogenicity of the Shigella bacterium: charge-assisted hydrogen bonding., Hortner SR, Ritschel T, Stengl B, Kramer C, Schweizer WB, Wagner B, Kansy M, Klebe G, Diederich F, Angew Chem Int Ed Engl. 2007;46(43):8266-9. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17902085 17902085] |
[[Category: Queuine tRNA-ribosyltransferase]] | [[Category: Queuine tRNA-ribosyltransferase]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| Line 30: | Line 30: | ||
[[Category: zinc]] | [[Category: zinc]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 23 12:12:54 2008'' |
Revision as of 10:12, 23 January 2008
|
tRNA-Guanine Transglycosylase(TGT) in Complex with 6-amino-2-[(1-naphthylmethyl)amino]-3,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one
About this Structure
2QZR is a Single protein structure of sequence from Zymomonas mobilis with , and as ligands. Active as Queuine tRNA-ribosyltransferase, with EC number 2.4.2.29 Full crystallographic information is available from OCA.
Reference
Potent inhibitors of tRNA-guanine transglycosylase, an enzyme linked to the pathogenicity of the Shigella bacterium: charge-assisted hydrogen bonding., Hortner SR, Ritschel T, Stengl B, Kramer C, Schweizer WB, Wagner B, Kansy M, Klebe G, Diederich F, Angew Chem Int Ed Engl. 2007;46(43):8266-9. PMID:17902085
Page seeded by OCA on Wed Jan 23 12:12:54 2008
Categories: Queuine tRNA-ribosyltransferase | Single protein | Zymomonas mobilis | Diederich, F. | Hoertner, S.R. | Kansy, M. | Klebe, G. | Kramer, C. | Ritschel, T. | Schweizer, W.B. | Stengl, B. | Wagner, B. | GOL | S79 | ZN | Glycosyltransferase | Metal-binding | Queuosine biosynthesis | Transferase | Trna processing | Zinc
