2bmj
From Proteopedia
(New page: 200px<br /> <applet load="2bmj" size="450" color="white" frame="true" align="right" spinBox="true" caption="2bmj, resolution 2.10Å" /> '''GTPASE LIKE DOMAIN ...) |
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| - | [[Image:2bmj.gif|left|200px]]<br /> | + | [[Image:2bmj.gif|left|200px]]<br /><applet load="2bmj" size="350" color="white" frame="true" align="right" spinBox="true" |
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caption="2bmj, resolution 2.10Å" /> | caption="2bmj, resolution 2.10Å" /> | ||
'''GTPASE LIKE DOMAIN OF CENTAURIN GAMMA 1 (HUMAN)'''<br /> | '''GTPASE LIKE DOMAIN OF CENTAURIN GAMMA 1 (HUMAN)'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2BMJ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http:// | + | 2BMJ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BMJ OCA]. |
==Reference== | ==Reference== | ||
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[[Category: structural genomics consortium]] | [[Category: structural genomics consortium]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 23 12:19:06 2008'' |
Revision as of 10:19, 23 January 2008
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GTPASE LIKE DOMAIN OF CENTAURIN GAMMA 1 (HUMAN)
Overview
Centaurins are a family of proteins that contain GTPase-activating protein, domains, with the gamma family members containing in addition a, GTPase-like domain. Centaurins reside mainly in the nucleus and are known, to activate phosphoinositide 3-kinase, a key regulator of cell, proliferation, motility and vesicular trafficking. In the present study, using X-ray structural analysis, enzymatic assays and nucleotide-binding, studies, we show that, for CENTG1 (centaurin gamma-1) the GTPase-like, domain has broader trinucleotide specificity. Alterations within the G4, motif of CENTG1 from the highly conserved NKXD found in typical GTPases to, TQDR result in the loss of specificity, a lower affinity for the, nucleotides and higher turnover rates. These results indicate that the, centaurins could be more accurately classified as NTPases and point to, alternative mechanisms of cell signalling control.
About this Structure
2BMJ is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
The centaurin gamma-1 GTPase-like domain functions as an NTPase., Soundararajan M, Yang X, Elkins JM, Sobott F, Doyle DA, Biochem J. 2007 Feb 1;401(3):679-88. PMID:17037982
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