2ebo
From Proteopedia
(New page: 200px<br /> <applet load="2ebo" size="450" color="white" frame="true" align="right" spinBox="true" caption="2ebo, resolution 1.90Å" /> '''CORE STRUCTURE OF G...) |
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==About this Structure== | ==About this Structure== | ||
| - | 2EBO is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/ | + | 2EBO is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Ebola_virus_sp. Ebola virus sp.]] with CL as [[http://en.wikipedia.org/wiki/ligand ligand]]. Structure known Active Site: CL. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2EBO OCA]]. |
==Reference== | ==Reference== | ||
Core structure of the envelope glycoprotein GP2 from Ebola virus at 1.9-A resolution., Malashkevich VN, Schneider BJ, McNally ML, Milhollen MA, Pang JX, Kim PS, Proc Natl Acad Sci U S A. 1999 Mar 16;96(6):2662-7. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10077567 10077567] | Core structure of the envelope glycoprotein GP2 from Ebola virus at 1.9-A resolution., Malashkevich VN, Schneider BJ, McNally ML, Milhollen MA, Pang JX, Kim PS, Proc Natl Acad Sci U S A. 1999 Mar 16;96(6):2662-7. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10077567 10077567] | ||
| - | [[Category: Ebola virus]] | + | [[Category: Ebola virus sp.]] |
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Kim, P.S.]] | [[Category: Kim, P.S.]] | ||
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[[Category: gp2]] | [[Category: gp2]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 11:18:57 2007'' |
Revision as of 09:14, 30 October 2007
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CORE STRUCTURE OF GP2 FROM EBOLA VIRUS
Overview
Ebola virions contain a surface transmembrane glycoprotein (GP) that is, responsible for binding to target cells and subsequent fusion of the viral, and host-cell membranes. GP is expressed as a single-chain precursor that, is posttranslationally processed into the disulfide-linked fragments GP1, and GP2. The GP2 subunit is thought to mediate membrane fusion. A soluble, fragment of the GP2 ectodomain, lacking the fusion-peptide region and the, transmembrane helix, folds into a stable, highly helical structure in, aqueous solution. Limited proteolysis studies identify a stable core of, the GP2 ectodomain. This 74-residue core, denoted Ebo-74, was, crystallized, and its x-ray structure was determined at 1.9-A resolution., Ebo-74 forms a trimer in which a long, central three-stranded coiled ... [(full description)]
About this Structure
2EBO is a [Single protein] structure of sequence from [Ebola virus sp.] with CL as [ligand]. Structure known Active Site: CL. Full crystallographic information is available from [OCA].
Reference
Core structure of the envelope glycoprotein GP2 from Ebola virus at 1.9-A resolution., Malashkevich VN, Schneider BJ, McNally ML, Milhollen MA, Pang JX, Kim PS, Proc Natl Acad Sci U S A. 1999 Mar 16;96(6):2662-7. PMID:10077567
Page seeded by OCA on Tue Oct 30 11:18:57 2007
