2r6e
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(New page: 200px<br /><applet load="2r6e" size="350" color="white" frame="true" align="right" spinBox="true" caption="2r6e, resolution 5.019Å" /> '''Crystal Form B2'''<...)
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Revision as of 10:24, 23 January 2008
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Crystal Form B2
Overview
The complex between the DnaB helicase and the DnaG primase unwinds duplex, DNA at the eubacterial replication fork and synthesizes the Okazaki RNA, primers. The crystal structures of hexameric DnaB and its complex with the, helicase binding domain (HBD) of DnaG reveal that within the hexamer the, two domains of DnaB pack with strikingly different symmetries to form a, distinct two-layered ring structure. Each of three bound HBDs stabilizes, the DnaB hexamer in a conformation that may increase its processivity., Three positive, conserved electrostatic patches on the N-terminal domain, of DnaB may also serve as a binding site for DNA and thereby guide the DNA, to a DnaG active site.
About this Structure
2R6E is a Single protein structure of sequence from Geobacillus stearothermophilus with as ligand. Full crystallographic information is available from OCA.
Reference
Structure of hexameric DnaB helicase and its complex with a domain of DnaG primase., Bailey S, Eliason WK, Steitz TA, Science. 2007 Oct 19;318(5849):459-63. PMID:17947583
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