2j8i
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(New page: 200px<br /><applet load="2j8i" size="350" color="white" frame="true" align="right" spinBox="true" caption="2j8i, resolution 2.10Å" /> '''STRUCTURE OF NP275, ...)
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Revision as of 10:32, 23 January 2008
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STRUCTURE OF NP275, A PENTAPEPTIDE REPEAT PROTEIN FROM NOSTOC PUNCTIFORME
Overview
The Nostoc punctiforme genes Np275 and Np276 are two adjacently encoded, proteins of 98 and 75 amino acids in length and exhibit sequences composed, of tandem pentapeptide repeats. The structures of Np275 and a fusion of, Np275 and Np276 were determined to 2.1 and 1.5 A, respectively. The two, Nostoc proteins fold as highly symmetric right-handed quadrilateral, beta-helices similar to the mycobacterial protein MfpA implicated in, fluoroquinolone resistance and DNA gyrase inhibition. The sequence, composition of the intervening coding region and the ability to express a, fused protein by removing the stop codon for Np275 suggests Np275 and, Np276 were recently part of a larger ancestral pentapeptide repeat, protein.
About this Structure
2J8I is a Single protein structure of sequence from Nostoc punctiforme with as ligand. Full crystallographic information is available from OCA.
Reference
Structural characterization of the fusion of two pentapeptide repeat proteins, Np275 and Np276, from Nostoc punctiforme: resurrection of an ancestral protein., Vetting MW, Hegde SS, Hazleton KZ, Blanchard JS, Protein Sci. 2007 Apr;16(4):755-60. PMID:17384236
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