1uzz
From Proteopedia
(New page: 200px<br /> <applet load="1uzz" size="450" color="white" frame="true" align="right" spinBox="true" caption="1uzz, resolution 2.13Å" /> '''ERYTHRINA CRISTAGAL...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1UZZ is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/ | + | 1UZZ is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Eukaryota Eukaryota]] with CA, MN and GOL as [[http://en.wikipedia.org/wiki/ligands ligands]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1UZZ OCA]]. |
==Reference== | ==Reference== | ||
Crystal structures of Erythrina cristagalli lectin with bound N-linked oligosaccharide and lactose., Turton K, Natesh R, Thiyagarajan N, Chaddock JA, Acharya KR, Glycobiology. 2004 Oct;14(10):923-9. Epub 2004 Jun 16. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15201215 15201215] | Crystal structures of Erythrina cristagalli lectin with bound N-linked oligosaccharide and lactose., Turton K, Natesh R, Thiyagarajan N, Chaddock JA, Acharya KR, Glycobiology. 2004 Oct;14(10):923-9. Epub 2004 Jun 16. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15201215 15201215] | ||
| - | [[Category: | + | [[Category: Eukaryota]] |
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Acharya, K.R.]] | [[Category: Acharya, K.R.]] | ||
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[[Category: lectin]] | [[Category: lectin]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 11:20:32 2007'' |
Revision as of 09:15, 30 October 2007
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ERYTHRINA CRISTAGALLI BOUND TO N-LINKED OLIGOSACCHARIDE AND LACTOSE
Overview
Erythrina cristagalli lectin (ECL) is a galactose-specific legume lectin., Although its biological function in the legume is unknown, ECL exhibits, hemagglutinating activity in vitro and is mitogenic for T lymphocytes. In, addition, it has been recently shown that ECL forms a novel conjugate when, coupled to a catalytically active derivative of the type A neurotoxin from, Clostridium botulinum, thus providing a therapeutic potential. ECL is, biologically active as a dimer in which each protomer contains a, functional carbohydrate-combining site. The crystal structure of native, ECL was recently reported in complex with lactose and 2'-fucosyllactose., ECL protomers adopt the legume lectin fold but form non-canonical dimers, via the handshake motif as was previously observed for Erythrina, ... [(full description)]
About this Structure
1UZZ is a [Single protein] structure of sequence from [Eukaryota] with CA, MN and GOL as [ligands]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
Crystal structures of Erythrina cristagalli lectin with bound N-linked oligosaccharide and lactose., Turton K, Natesh R, Thiyagarajan N, Chaddock JA, Acharya KR, Glycobiology. 2004 Oct;14(10):923-9. Epub 2004 Jun 16. PMID:15201215
Page seeded by OCA on Tue Oct 30 11:20:32 2007
Categories: Eukaryota | Single protein | Acharya, K.R. | Chaddock, J.A. | Natesh, R. | Thiyagarajan, N. | Turton, K. | CA | GOL | MN | Carbohydrate binding | Lectin
