1uzn
From Proteopedia
(New page: 200px<br /> <applet load="1uzn" size="450" color="white" frame="true" align="right" spinBox="true" caption="1uzn, resolution 1.91Å" /> '''MABA FROM MYCOBACTE...) |
|||
| Line 8: | Line 8: | ||
==About this Structure== | ==About this Structure== | ||
| - | 1UZN is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]] with CS and NAP as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.100 1.1.1.100]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1UZN OCA]]. | + | 1UZN is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]] with CS and NAP as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/3-oxoacyl-[acyl-carrier-protein]_reductase 3-oxoacyl-[acyl-carrier-protein] reductase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.100 1.1.1.100]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1UZN OCA]]. |
==Reference== | ==Reference== | ||
Crystal structure of MabA from Mycobacterium tuberculosis, a reductase involved in long-chain fatty acid biosynthesis., Cohen-Gonsaud M, Ducasse S, Hoh F, Zerbib D, Labesse G, Quemard A, J Mol Biol. 2002 Jul 5;320(2):249-61. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12079383 12079383] | Crystal structure of MabA from Mycobacterium tuberculosis, a reductase involved in long-chain fatty acid biosynthesis., Cohen-Gonsaud M, Ducasse S, Hoh F, Zerbib D, Labesse G, Quemard A, J Mol Biol. 2002 Jul 5;320(2):249-61. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12079383 12079383] | ||
| + | [[Category: 3-oxoacyl-[acyl-carrier-protein] reductase]] | ||
[[Category: Mycobacterium tuberculosis]] | [[Category: Mycobacterium tuberculosis]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| Line 23: | Line 24: | ||
[[Category: oxidoreductase]] | [[Category: oxidoreductase]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 11:21:28 2007'' |
Revision as of 09:16, 30 October 2007
|
MABA FROM MYCOBACTERIUM TUBERCULOSIS
Overview
The fatty acid elongation system FAS-II is involved in the biosynthesis of, mycolic acids, which are major and specific long-chain fatty acids of the, cell envelope of Mycobacterium tuberculosis and other mycobacteria, including Mycobacterium smegmatis. The protein MabA, also named FabG1, has, been shown recently to be part of FAS-II and to catalyse the, NADPH-specific reduction of long chain beta-ketoacyl derivatives. This, activity corresponds to the second step of an FAS-II elongation round., FAS-II is inhibited by the antituberculous drug isoniazid through the, inhibition of the 2-trans-enoyl-acyl carrier protein reductase InhA. Thus, the other enzymes making up this enzymatic complex represent potential, targets for designing new antituberculous drugs. The crystal structure of, the ... [(full description)]
About this Structure
1UZN is a [Single protein] structure of sequence from [Mycobacterium tuberculosis] with CS and NAP as [ligands]. Active as [[acyl-carrier-protein_reductase 3-oxoacyl-[acyl-carrier-protein] reductase]], with EC number [1.1.1.100]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
Crystal structure of MabA from Mycobacterium tuberculosis, a reductase involved in long-chain fatty acid biosynthesis., Cohen-Gonsaud M, Ducasse S, Hoh F, Zerbib D, Labesse G, Quemard A, J Mol Biol. 2002 Jul 5;320(2):249-61. PMID:12079383 [[Category: 3-oxoacyl-[acyl-carrier-protein] reductase]]
Page seeded by OCA on Tue Oct 30 11:21:28 2007
