2r2w
From Proteopedia
(New page: 200px<br /> <applet load="2r2w" size="450" color="white" frame="true" align="right" spinBox="true" caption="2r2w, resolution 2.01Å" /> '''Urokinase plasminog...) |
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| - | [[Image:2r2w. | + | [[Image:2r2w.jpg|left|200px]]<br /><applet load="2r2w" size="350" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="2r2w" size=" | + | |
caption="2r2w, resolution 2.01Å" /> | caption="2r2w, resolution 2.01Å" /> | ||
'''Urokinase plasminogen activator B-chain-GPPE complex'''<br /> | '''Urokinase plasminogen activator B-chain-GPPE complex'''<br /> | ||
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==Overview== | ==Overview== | ||
Crystal structure of 2-(4-guanidynephenyl)-1-phenyl-ethanone (GPPE) in two, different environments was determined in order to compare the binding, geometry of these compound to a simple picrate anion and to protein, urokinase-type plasminogen activator (uPA), which may be treated as a, target for anti-cancer drugs. It was shown that the conformation and the, hydrogen-bonding formation by GPPE molecule are similar in both, environments, but several important differences were discovered and, described. | Crystal structure of 2-(4-guanidynephenyl)-1-phenyl-ethanone (GPPE) in two, different environments was determined in order to compare the binding, geometry of these compound to a simple picrate anion and to protein, urokinase-type plasminogen activator (uPA), which may be treated as a, target for anti-cancer drugs. It was shown that the conformation and the, hydrogen-bonding formation by GPPE molecule are similar in both, environments, but several important differences were discovered and, described. | ||
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| - | ==Disease== | ||
| - | Known disease associated with this structure: Alzheimer disease, late-onset, susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=191840 191840]] | ||
==About this Structure== | ==About this Structure== | ||
| - | 2R2W is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with SO4 and 4PG as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/U-plasminogen_activator U-plasminogen activator], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.73 3.4.21.73] Full crystallographic information is available from [http:// | + | 2R2W is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=SO4:'>SO4</scene> and <scene name='pdbligand=4PG:'>4PG</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/U-plasminogen_activator U-plasminogen activator], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.73 3.4.21.73] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R2W OCA]. |
==Reference== | ==Reference== | ||
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[[Category: urokinase]] | [[Category: urokinase]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 23 12:44:56 2008'' |
Revision as of 10:44, 23 January 2008
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Urokinase plasminogen activator B-chain-GPPE complex
Overview
Crystal structure of 2-(4-guanidynephenyl)-1-phenyl-ethanone (GPPE) in two, different environments was determined in order to compare the binding, geometry of these compound to a simple picrate anion and to protein, urokinase-type plasminogen activator (uPA), which may be treated as a, target for anti-cancer drugs. It was shown that the conformation and the, hydrogen-bonding formation by GPPE molecule are similar in both, environments, but several important differences were discovered and, described.
About this Structure
2R2W is a Single protein structure of sequence from Homo sapiens with and as ligands. Active as U-plasminogen activator, with EC number 3.4.21.73 Full crystallographic information is available from OCA.
Reference
Geometry of GPPE binding to picrate and to the urokinase type plasminogen activator., Zeslawska E, Sturzebecher J, Oleksyn BJ, Bioorg Med Chem Lett. 2007 Nov 15;17(22):6212-5. Epub 2007 Sep 8. PMID:17905583
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