2is0
From Proteopedia
(New page: 200px<br /> <applet load="2is0" size="450" color="white" frame="true" align="right" spinBox="true" caption="2is0, resolution 2.20Å" /> '''Crystal structure o...) |
|||
| Line 1: | Line 1: | ||
| - | [[Image:2is0.gif|left|200px]]<br /> | + | [[Image:2is0.gif|left|200px]]<br /><applet load="2is0" size="350" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="2is0" size=" | + | |
caption="2is0, resolution 2.20Å" /> | caption="2is0, resolution 2.20Å" /> | ||
'''Crystal structure of human Beta-secretase complexed with inhibitor'''<br /> | '''Crystal structure of human Beta-secretase complexed with inhibitor'''<br /> | ||
| Line 8: | Line 7: | ||
==About this Structure== | ==About this Structure== | ||
| - | 2IS0 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with I03 as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] Full crystallographic information is available from [http:// | + | 2IS0 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=I03:'>I03</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IS0 OCA]. |
==Reference== | ==Reference== | ||
| Line 20: | Line 19: | ||
[[Category: hydrolase]] | [[Category: hydrolase]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 23 12:49:03 2008'' |
Revision as of 10:49, 23 January 2008
|
Crystal structure of human Beta-secretase complexed with inhibitor
Overview
We describe the discovery and optimization of tertiary carbinamine derived, inhibitors of the enzyme beta-secretase (BACE-1). These novel, non-transition-state-derived ligands incorporate a single primary amine to, interact with the catalytic aspartates of the target enzyme. Optimization, of this series provided inhibitors with intrinsic and functional potency, comparable to evolved transition state isostere derived inhibitors of, BACE-1.
About this Structure
2IS0 is a Single protein structure of sequence from Homo sapiens with as ligand. Active as Memapsin 2, with EC number 3.4.23.46 Full crystallographic information is available from OCA.
Reference
Discovery of oxadiazoyl tertiary carbinamine inhibitors of beta-secretase (BACE-1)., Rajapakse HA, Nantermet PG, Selnick HG, Munshi S, McGaughey GB, Lindsley SR, Young MB, Lai MT, Espeseth AS, Shi XP, Colussi D, Pietrak B, Crouthamel MC, Tugusheva K, Huang Q, Xu M, Simon AJ, Kuo L, Hazuda DJ, Graham S, Vacca JP, J Med Chem. 2006 Dec 14;49(25):7270-3. PMID:17149856
Page seeded by OCA on Wed Jan 23 12:49:03 2008
