2uuv
From Proteopedia
(New page: 200px<br /> <applet load="2uuv" size="450" color="white" frame="true" align="right" spinBox="true" caption="2uuv, resolution 1.99Å" /> '''ALKYLDIHYDROXYACETO...) |
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==About this Structure== | ==About this Structure== | ||
| - | 2UUV is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Dictyostelium_discoideum Dictyostelium discoideum]] with FAD and PL3 as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.26 2.5.1.26]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2UUV OCA]]. | + | 2UUV is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Dictyostelium_discoideum Dictyostelium discoideum]] with FAD and PL3 as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/Alkylglycerone-phosphate_synthase Alkylglycerone-phosphate synthase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.26 2.5.1.26]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2UUV OCA]]. |
==Reference== | ==Reference== | ||
The crucial step in ether phospholipid biosynthesis: structural basis of a noncanonical reaction associated with a peroxisomal disorder., Razeto A, Mattiroli F, Carpanelli E, Aliverti A, Pandini V, Coda A, Mattevi A, Structure. 2007 Jun;15(6):683-92. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17562315 17562315] | The crucial step in ether phospholipid biosynthesis: structural basis of a noncanonical reaction associated with a peroxisomal disorder., Razeto A, Mattiroli F, Carpanelli E, Aliverti A, Pandini V, Coda A, Mattevi A, Structure. 2007 Jun;15(6):683-92. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17562315 17562315] | ||
| + | [[Category: Alkylglycerone-phosphate synthase]] | ||
[[Category: Dictyostelium discoideum]] | [[Category: Dictyostelium discoideum]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: transferase]] | [[Category: transferase]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 11:24:14 2007'' |
Revision as of 09:19, 30 October 2007
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ALKYLDIHYDROXYACETONEPHOSPHATE SYNTHASE IN P1
Overview
Ether phospholipids are essential constituents of eukaryotic cell, membranes. Rhizomelic chondrodysplasia punctata type 3 is a severe, peroxisomal disorder caused by inborn deficiency of, alkyldihydroxyacetonephosphate synthase (ADPS). The enzyme carries out the, most characteristic step in ether phospholipid biosynthesis: formation of, the ether bond. The crystal structure of ADPS from Dictyostelium, discoideum shows a fatty-alcohol molecule bound in a narrow hydrophobic, tunnel, specific for aliphatic chains of 16 carbons. Access to the tunnel, is controlled by a flexible loop and a gating helix at the, protein-membrane interface. Structural and mutagenesis investigations, identify a cluster of hydrophilic catalytic residues, including an, essential tyrosine, possibly involved in ... [(full description)]
About this Structure
2UUV is a [Single protein] structure of sequence from [Dictyostelium discoideum] with FAD and PL3 as [ligands]. Active as [Alkylglycerone-phosphate synthase], with EC number [2.5.1.26]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
The crucial step in ether phospholipid biosynthesis: structural basis of a noncanonical reaction associated with a peroxisomal disorder., Razeto A, Mattiroli F, Carpanelli E, Aliverti A, Pandini V, Coda A, Mattevi A, Structure. 2007 Jun;15(6):683-92. PMID:17562315
Page seeded by OCA on Tue Oct 30 11:24:14 2007
Categories: Alkylglycerone-phosphate synthase | Dictyostelium discoideum | Single protein | Aliverti, A. | Carpanelli, E. | Coda, A. | Mattevi, A. | Mattiroli, F. | Pandini, V. | Razeto, A. | FAD | PL3 | Biosynthesis of phospholipids | Fad | Flavin | Flavoprotein | Lipid synthesis | Peroxisomal disorder | Peroxisome | Plasmalogens | Rhizomelic chondrodysplasia punctata | Transferase
