2qu4
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(New page: 200px<br /><applet load="2qu4" size="350" color="white" frame="true" align="right" spinBox="true" caption="2qu4" /> '''Model for Bacterial ParM Filament'''<br /> ...)
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Revision as of 10:51, 23 January 2008
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Model for Bacterial ParM Filament
Overview
Bacterial ParM is a homolog of eukaryotic actin and is involved in moving, plasmids so that they segregate properly during cell division. Using, cryo-EM and three-dimensional reconstruction, we show that ParM filaments, have a different structure from F-actin, with very different, subunit-subunit interfaces. These interfaces result in the helical, handedness of the ParM filament being opposite to that of F-actin. Like, F-actin, ParM filaments have a variable twist, and we show that this, involves domain-domain rotations within the ParM subunit. The present, results yield new insights into polymorphisms within F-actin, as well as, the evolution of polymer families.
About this Structure
2QU4 is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.
Reference
The structure of bacterial ParM filaments., Orlova A, Garner EC, Galkin VE, Heuser J, Mullins RD, Egelman EH, Nat Struct Mol Biol. 2007 Oct;14(10):921-6. Epub 2007 Sep 16. PMID:17873883
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