3jyt
From Proteopedia
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==About this Structure== | ==About this Structure== | ||
| - | + | [[3jyt]] is a 4 chain structure of [[Reverse transcriptase]] with sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JYT OCA]. | |
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| + | ==See Also== | ||
| + | *[[Reverse transcriptase]] | ||
==Reference== | ==Reference== | ||
<ref group="xtra">PMID:19812032</ref><ref group="xtra">PMID:15107837</ref><references group="xtra"/> | <ref group="xtra">PMID:19812032</ref><ref group="xtra">PMID:15107837</ref><references group="xtra"/> | ||
| - | [[Category: Human immunodeficiency virus | + | [[Category: Human immunodeficiency virus 1]] |
[[Category: RNA-directed DNA polymerase]] | [[Category: RNA-directed DNA polymerase]] | ||
[[Category: Arnold, E.]] | [[Category: Arnold, E.]] | ||
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[[Category: Tenofovir]] | [[Category: Tenofovir]] | ||
[[Category: Transferase/dna complex]] | [[Category: Transferase/dna complex]] | ||
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| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 16 13:16:18 2009'' | ||
Revision as of 01:00, 27 December 2010
Contents |
K65R mutant HIV-1 reverse transcriptase cross-linked to DS-DNA and complexed with DATP as the incoming nucleotide substrate
Template:ABSTRACT PUBMED 19812032
About this Structure
3jyt is a 4 chain structure of Reverse transcriptase with sequence from Human immunodeficiency virus 1. Full crystallographic information is available from OCA.
See Also
Reference
- Das K, Bandwar RP, White KL, Feng JY, Sarafianos SG, Tuske S, Tu X, Clark AD Jr, Boyer PL, Hou X, Gaffney BL, Jones RA, Miller MD, Hughes SH, Arnold E. Structural basis for the role of the K65R mutation in HIV-1 reverse transcriptase polymerization, excision antagonism, and tenofovir resistance. J Biol Chem. 2009 Dec 11;284(50):35092-100. Epub 2009 Oct 7. PMID:19812032 doi:10.1074/jbc.M109.022525
- Tuske S, Sarafianos SG, Clark AD Jr, Ding J, Naeger LK, White KL, Miller MD, Gibbs CS, Boyer PL, Clark P, Wang G, Gaffney BL, Jones RA, Jerina DM, Hughes SH, Arnold E. Structures of HIV-1 RT-DNA complexes before and after incorporation of the anti-AIDS drug tenofovir. Nat Struct Mol Biol. 2004 May;11(5):469-74. Epub 2004 Apr 25. PMID:15107837 doi:10.1038/nsmb760
Categories: Human immunodeficiency virus 1 | RNA-directed DNA polymerase | Arnold, E. | Das, K. | Aid | Dna recombination | Dna-directed dna polymerase | Drug resistance mutation | Hiv-1 reverse transcriptase | Hydrolase | Lipoprotein | Magnesium | Membrane | Metal-binding | Multifunctional enzyme | Nucleotidyltransferase | Rna-directed dna polymerase transferase | Rnase h | Rt-dna complex | Tenofovir | Transferase/dna complex
