2q2z
From Proteopedia
(New page: 200px<br /> <applet load="2q2z" size="450" color="white" frame="true" align="right" spinBox="true" caption="2q2z, resolution 3.00Å" /> '''Crystal Structure o...) |
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| - | [[Image:2q2z. | + | [[Image:2q2z.jpg|left|200px]]<br /><applet load="2q2z" size="350" color="white" frame="true" align="right" spinBox="true" |
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caption="2q2z, resolution 3.00Å" /> | caption="2q2z, resolution 3.00Å" /> | ||
'''Crystal Structure of KSP in Complex with Inhibitor 22'''<br /> | '''Crystal Structure of KSP in Complex with Inhibitor 22'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2Q2Z is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with MG, ADP and MKK as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http:// | + | 2Q2Z is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=MG:'>MG</scene>, <scene name='pdbligand=ADP:'>ADP</scene> and <scene name='pdbligand=MKK:'>MKK</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q2Z OCA]. |
==Reference== | ==Reference== | ||
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[[Category: ksp-inhibitor complex]] | [[Category: ksp-inhibitor complex]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 23 12:57:32 2008'' |
Revision as of 10:57, 23 January 2008
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Crystal Structure of KSP in Complex with Inhibitor 22
Overview
Inspired by previous efforts in the pyrazolobenzoxazine class of KSP, inhibitors, the design and synthesis of 1,4-diaryl-4,5-dihydropyrazole, inhibitors of KSP are described. Crystallographic evidence of binding mode, and in vivo potency data is also highlighted.
About this Structure
2Q2Z is a Single protein structure of sequence from Homo sapiens with , and as ligands. Full crystallographic information is available from OCA.
Reference
Kinesin spindle protein (KSP) inhibitors. Part 8: Design and synthesis of 1,4-diaryl-4,5-dihydropyrazoles as potent inhibitors of the mitotic kinesin KSP., Roecker AJ, Coleman PJ, Mercer SP, Schreier JD, Buser CA, Walsh ES, Hamilton K, Lobell RB, Tao W, Diehl RE, South VJ, Davide JP, Kohl NE, Yan Y, Kuo LC, Li C, Fernandez-Metzler C, Mahan EA, Prueksaritanont T, Hartman GD, Bioorg Med Chem Lett. 2007 Oct 15;17(20):5677-82. Epub 2007 Aug 21. PMID:17766111
Page seeded by OCA on Wed Jan 23 12:57:32 2008
Categories: Homo sapiens | Single protein | Yan, Y. | ADP | MG | MKK | Cell cycle | Ksp | Ksp-inhibitor complex
