2qad
From Proteopedia
(New page: 200px<br /> <applet load="2qad" size="450" color="white" frame="true" align="right" spinBox="true" caption="2qad, resolution 3.3Å" /> '''Structure of tyrosin...) |
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| - | [[Image:2qad.gif|left|200px]]<br /> | + | [[Image:2qad.gif|left|200px]]<br /><applet load="2qad" size="350" color="white" frame="true" align="right" spinBox="true" |
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caption="2qad, resolution 3.3Å" /> | caption="2qad, resolution 3.3Å" /> | ||
'''Structure of tyrosine-sulfated 412d antibody complexed with HIV-1 YU2 gp120 and CD4'''<br /> | '''Structure of tyrosine-sulfated 412d antibody complexed with HIV-1 YU2 gp120 and CD4'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2QAD is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1] with NAG, MLA and EDO as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http:// | + | 2QAD is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1] with <scene name='pdbligand=NAG:'>NAG</scene>, <scene name='pdbligand=MLA:'>MLA</scene> and <scene name='pdbligand=EDO:'>EDO</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QAD OCA]. |
==Reference== | ==Reference== | ||
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[[Category: viral protein/immune system]] | [[Category: viral protein/immune system]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 23 12:58:05 2008'' |
Revision as of 10:58, 23 January 2008
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Structure of tyrosine-sulfated 412d antibody complexed with HIV-1 YU2 gp120 and CD4
Overview
The CCR5 co-receptor binds to the HIV-1 gp120 envelope glycoprotein and, facilitates HIV-1 entry into cells. Its N terminus is tyrosine-sulfated, as are many antibodies that react with the co-receptor binding site on, gp120. We applied nuclear magnetic resonance and crystallographic, techniques to analyze the structure of the CCR5 N terminus and that of the, tyrosine-sulfated antibody 412d in complex with gp120 and CD4. The, conformations of tyrosine-sulfated regions of CCR5 (alpha-helix) and 412d, (extended loop) are surprisingly different. Nonetheless, a critical, sulfotyrosine on CCR5 and on 412d induces similar structural, rearrangements in gp120. These results now provide a framework for, understanding HIV-1 interactions with the CCR5 N terminus during viral, entry and define a conserved site on gp120, whose recognition of, sulfotyrosine engenders posttranslational mimicry by the immune system.
About this Structure
2QAD is a Protein complex structure of sequences from Homo sapiens and Human immunodeficiency virus 1 with , and as ligands. Full crystallographic information is available from OCA.
Reference
Structures of the CCR5 N terminus and of a tyrosine-sulfated antibody with HIV-1 gp120 and CD4., Huang CC, Lam SN, Acharya P, Tang M, Xiang SH, Hussan SS, Stanfield RL, Robinson J, Sodroski J, Wilson IA, Wyatt R, Bewley CA, Kwong PD, Science. 2007 Sep 28;317(5846):1930-4. PMID:17901336
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