Proteasome
From Proteopedia
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[[3gpt]], [[3gpw]], [[1g0u]] – y20S core - yeast<br /> | [[3gpt]], [[3gpw]], [[1g0u]] – y20S core - yeast<br /> | ||
[[1ryp]] - y20S core (mutant)<br /> | [[1ryp]] - y20S core (mutant)<br /> | ||
| + | [[2zcy]] – y20S+syringolin<br /> | ||
[[3mka]], [[3hfa]] – Mt20S core (mutant)<br /> | [[3mka]], [[3hfa]] – Mt20S core (mutant)<br /> | ||
[[3c91]], [[3c92]], [[1pma]] – Ta20S core - ''Themoplasma acidophilum''<br /> | [[3c91]], [[3c92]], [[1pma]] – Ta20S core - ''Themoplasma acidophilum''<br /> | ||
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| - | [[3hye]], [[3gpj]], [[3dy3]], [[3dy4]], [[3e47]], [[3d29]], [[3bdm]], [[2gpl]], [[2fak]], [[2f16]], [[1jd2]], [[1g65]] – y20S core+inhibitor<br /> | + | [[3hye]], [[3gpj]], [[3dy3]], [[3dy4]], [[3e47]], [[3d29]], [[3zcy]], [[3bdm]], [[2gpl]], [[2fak]], [[2f16]], [[1jd2]], [[1g65]] – y20S core+inhibitor<br /> |
| - | [[3h6f]], [[3h6i]], [[3hf9]], [[2fhh]] – Mt20S core+inhibitor<br /> | + | [[3h6f]], [[3h6i]], [[3hf9]], [[2fhh]], [[3krd]] – Mt20S core+inhibitor<br /> |
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[[3fp9]] – MtATPase chains A-L<br /> | [[3fp9]] – MtATPase chains A-L<br /> | ||
[[1j2p]] – Af α subunit<br /> | [[1j2p]] – Af α subunit<br /> | ||
| + | [[2jay]] – Mt β subunit<br /> | ||
| + | [[2kqz]], [[2kr0]] – hPRTS ubiquitin receptor domain | ||
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| + | ===Partial 26S=== | ||
| + | |||
| + | [[1p9c]] – hPRTS subunit 4 C-terminal – human<br /> | ||
| + | [[1p9d]] - hPRTS subunit 4 C-terminal + HHR23A ubiquitin-like domain<br /> | ||
| + | [[1uel]] - hPRTS subunit 4 C-terminal + HHR23A ubiquitin-like domain - NMR<br /> | ||
| + | [[1yx4]] - hPRTS subunit 4 – NMR<br /> | ||
| + | [[1yx5]], [[1yx6]], [[2kde]], [[2kdf]] - hPRTS subunit 4+ubiquitin – NMR<br /> | ||
| + | [[2o95]], [[2o96]] - hPRTS subunit 7<br /> | ||
| + | [[3kw6]] - hPRTS subunit 8<br /> | ||
| + | [[2krk]] - hPRTS subunit 8 – NMR<br /> | ||
| + | [[1qym]], [[1uoh]] - hPRTS subunit 10<br /> | ||
| + | [[1tr4]] - hPRTS subunit 10 – NMR<br /> | ||
| + | [[2dvw]], [[2dwz]] - mPRTS subunit 10 + hPRTS subunit 6B – mouse<br /> | ||
| + | [[3aji]] - mPRTS subunit 10 + subunit 4<br /> | ||
| + | [[2x5n]] - PRTS subunit RPN10 VWA domain – fission yeast<br /> | ||
| + | [[2z4d]] - yPRTS subunit RPN13<br /> | ||
| + | [[2z59]] - mPRTS subunit RPN13+ubiquitin | ||
| + | |||
| + | |||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 11:04, 27 December 2010
Proteasome (PRTS) are large protein complexes which degrade unneeded proteins into small polypeptides. The 26S PRTS is composed of a central 20S core particle which contains 4 stacked rings each with several members and two 19S caps. The core particle two outer rings contain 7 alpha subunits which form the PRTS gate. The two inner rings contain 6 beta subunits with protease activity. The 19S cap is composed of a base with 10 proteins six of which are ATPases and a lid which contains 9 proteins which binds polyubiquitin. The images at the left and at the right correspond to one representative Proteasome, i.e. the crystal structure of yeast Proteasome (3gpt).
Contents |
3D Structures of Proteasome
20S particle
3mfe, 3mi0, 2fhg – Mt20S core – Mycobacterium tuberculosis
3gpt, 3gpw, 1g0u – y20S core - yeast
1ryp - y20S core (mutant)
2zcy – y20S+syringolin
3mka, 3hfa – Mt20S core (mutant)
3c91, 3c92, 1pma – Ta20S core - Themoplasma acidophilum
3h4p – 20S core – Methanocaldococcus janaschii
2h6j, 1q5r – Re20S core (mutant) – Rhodococcus erythropolis
1q5q - Re20S core
1j2q – Af20S core - Archaeoglobus fulgidus
1iru – 20S core - bovine
20S+activator protein
1vsy, 1l5q – y20S core+ Blm10
1z7q, 1fnt – y20S core+PA26
3ipm, 3jrm, 3jse, 3jtl, 1ya7, 1yar, 1yau - Taa-PRTS chains A-G+ Tab-PRTS chains H-N+PA26 chains O-U
20S+inhibitor
3hye, 3gpj, 3dy3, 3dy4, 3e47, 3d29, 3zcy, 3bdm, 2gpl, 2fak, 2f16, 1jd2, 1g65 – y20S core+inhibitor
3h6f, 3h6i, 3hf9, 2fhh, 3krd – Mt20S core+inhibitor
Partial 20S
2ku1, 2ku2 – Taa-PRTS chains A-G
3fp9 – MtATPase chains A-L
1j2p – Af α subunit
2jay – Mt β subunit
2kqz, 2kr0 – hPRTS ubiquitin receptor domain
Partial 26S
1p9c – hPRTS subunit 4 C-terminal – human
1p9d - hPRTS subunit 4 C-terminal + HHR23A ubiquitin-like domain
1uel - hPRTS subunit 4 C-terminal + HHR23A ubiquitin-like domain - NMR
1yx4 - hPRTS subunit 4 – NMR
1yx5, 1yx6, 2kde, 2kdf - hPRTS subunit 4+ubiquitin – NMR
2o95, 2o96 - hPRTS subunit 7
3kw6 - hPRTS subunit 8
2krk - hPRTS subunit 8 – NMR
1qym, 1uoh - hPRTS subunit 10
1tr4 - hPRTS subunit 10 – NMR
2dvw, 2dwz - mPRTS subunit 10 + hPRTS subunit 6B – mouse
3aji - mPRTS subunit 10 + subunit 4
2x5n - PRTS subunit RPN10 VWA domain – fission yeast
2z4d - yPRTS subunit RPN13
2z59 - mPRTS subunit RPN13+ubiquitin
Proteopedia Page Contributors and Editors (what is this?)
Michal Harel, Alexander Berchansky, Jaime Prilusky, Joel L. Sussman
