2hyy

(Difference between revisions)

Revision as of 13:14, 28 December 2010

2hyy, resolution 2.40Å ()

Ligands:

Gene:

ABL1 (Homo sapiens)

Activity:

Related:

1iep, 1fpu

Structural annotation:
Resources:	InterPro : Ipr015015, Ipr000980, Ipr000719, Ipr011009, Ipr001245, Ipr008266, Ipr001452 Pfam : PF07714 UniProt : P00519

Functional annotation:
Cellular component:	cytoplasm nucleus cytoskeleton
Biological process:	actin cytoskeleton organization and biogenesis protein amino acid phosphorylation peptidyl-tyrosine phosphorylation intracellular signaling cascade mismatch repair DNA damage response, signal transduction resulting in induction of apoptosis S-phase-specific transcription in mitotic cell cycle regulation of transcription, DNA-dependent cell adhesion protein modification process
Molecular function:	ATP binding transferase activity protein-tyrosine kinase activity protein C-terminus binding nucleotide binding manganese ion binding magnesium ion binding protein kinase activity kinase activity protein binding DNA binding metal ion binding

Evolutionary conservation:

Toggle Conservation Colors:	Rows = identical sequences:
Further Information:	Caveats, Explanation, Complete Results at ConSurfDB

Resources:

FirstGlance, OCA, RCSB, PDBsum

Coordinates:

save as pdb, mmCIF, xml

2hyy is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Cowan-Jacob SW, Fendrich G, Floersheimer A, Furet P, Liebetanz J, Rummel G, Rheinberger P, Centeleghe M, Fabbro D, Manley PW. Structural biology contributions to the discovery of drugs to treat chronic myelogenous leukaemia. Acta Crystallogr D Biol Crystallogr. 2007 Jan;63(Pt 1):80-93. Epub 2006, Dec 13. PMID:17164530 doi:http://dx.doi.org/10.1107/S0907444906047287

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-{{Seed}}
 [[Image:2hyy.png|left|200px]]
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 -->
 {{ABSTRACT_PUBMED_17164530}}
-==Disease==
-Known disease associated with this structure: Leukemia, Philadelphia chromosome-positive, resistant to imatinib OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=189980 189980]]
 ==About this Structure==
-HYY is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HYY OCA].
+[[2hyy]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HYY OCA].
+==See Also==
+*[[Imatinib]]
 ==Reference==
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 [[Category: Liebetanz, J.]]
 [[Category: Manley, P.]]
+[[Category: Transferase]]
 [[Category: Tyrosine kinase]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 00:39:09 2009''