1z6j
From Proteopedia
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[[Image:1z6j.png|left|200px]] | [[Image:1z6j.png|left|200px]] | ||
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{{ABSTRACT_PUBMED_15913999}} | {{ABSTRACT_PUBMED_15913999}} | ||
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| - | ==Disease== | ||
| - | Known disease associated with this structure: Factor VII deficiency OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=227500 227500]], Myocardial infarction, decreased susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=227500 227500]] | ||
==About this Structure== | ==About this Structure== | ||
| - | + | [[1z6j]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z6J OCA]. | |
==Reference== | ==Reference== | ||
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[[Category: Enzyme inhibitor complex]] | [[Category: Enzyme inhibitor complex]] | ||
[[Category: Gla]] | [[Category: Gla]] | ||
| + | [[Category: Hydrolase]] | ||
[[Category: Pyrazinone]] | [[Category: Pyrazinone]] | ||
[[Category: Serine protease]] | [[Category: Serine protease]] | ||
[[Category: Thrombosis]] | [[Category: Thrombosis]] | ||
[[Category: Tissue factor]] | [[Category: Tissue factor]] | ||
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| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 03:02:57 2009'' | ||
Revision as of 17:47, 29 December 2010
Crystal Structure of a ternary complex of Factor VIIa/Tissue Factor/Pyrazinone Inhibitor
Template:ABSTRACT PUBMED 15913999
About this Structure
1z6j is a 3 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Schweitzer BA, Neumann WL, Rahman HK, Kusturin CL, Sample KR, Poda GI, Kurumbail RG, Stevens AM, Stegeman RA, Stallings WC, South MS. Structure-based design and synthesis of pyrazinones containing novel P1 'side pocket' moieties as inhibitors of TF/VIIa. Bioorg Med Chem Lett. 2005 Jun 15;15(12):3006-11. PMID:15913999 doi:10.1016/j.bmcl.2005.04.037
- South MS, Case BL, Wood RS, Jones DE, Hayes MJ, Girard TJ, Lachance RM, Nicholson NS, Clare M, Stevens AM, Stegeman RA, Stallings WC, Kurumbail RG, Parlow JJ. Structure-based drug design of pyrazinone antithrombotics as selective inhibitors of the tissue factor VIIa complex. Bioorg Med Chem Lett. 2003 Jul 21;13(14):2319-25. PMID:12824026
- Parlow JJ, Dice TA, Lachance RM, Girard TJ, Stevens AM, Stegeman RA, Stallings WC, Kurumbail RG, South MS. Polymer-assisted solution-phase library synthesis and crystal structure of alpha-ketothiazoles as tissue factor VIIa inhibitors. J Med Chem. 2003 Sep 11;46(19):4043-9. PMID:12954057 doi:http://dx.doi.org/10.1021/jm030130t
Categories: Coagulation factor VIIa | Homo sapiens | Kurumbail, R G. | Kusturin, C L. | Neumann, W L. | Poda, G I. | Rahman, H K. | Sample, K R. | Schweitzer, B A. | Stallings, W C. | Stegeman, R A. | Stevens, A M. | Benzamidine | Blood coagulation | Cofactor | Enzyme inhibitor complex | Gla | Hydrolase | Pyrazinone | Serine protease | Thrombosis | Tissue factor
