2j12
From Proteopedia
(New page: 200px<br /> <applet load="2j12" size="450" color="white" frame="true" align="right" spinBox="true" caption="2j12, resolution 1.50Å" /> '''AD37 FIBRE HEAD IN ...) |
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==About this Structure== | ==About this Structure== | ||
| - | 2J12 is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] and [[http://en.wikipedia.org/wiki/ | + | 2J12 is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] and [[http://en.wikipedia.org/wiki/Human_adenovirus_type_49 Human adenovirus type 49]] with CA as [[http://en.wikipedia.org/wiki/ligand ligand]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2J12 OCA]]. |
==Reference== | ==Reference== | ||
Structural and mutational analysis of human Ad37 and canine adenovirus 2 fiber heads in complex with the D1 domain of coxsackie and adenovirus receptor., Seiradake E, Lortat-Jacob H, Billet O, Kremer EJ, Cusack S, J Biol Chem. 2006 Nov 3;281(44):33704-16. Epub 2006 Aug 21. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16923808 16923808] | Structural and mutational analysis of human Ad37 and canine adenovirus 2 fiber heads in complex with the D1 domain of coxsackie and adenovirus receptor., Seiradake E, Lortat-Jacob H, Billet O, Kremer EJ, Cusack S, J Biol Chem. 2006 Nov 3;281(44):33704-16. Epub 2006 Aug 21. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16923808 16923808] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Human adenovirus type | + | [[Category: Human adenovirus type 49]] |
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
[[Category: Billet, O.]] | [[Category: Billet, O.]] | ||
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[[Category: x-ray]] | [[Category: x-ray]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 11:26:39 2007'' |
Revision as of 09:21, 30 October 2007
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AD37 FIBRE HEAD IN COMPLEX WITH CAR D1
Overview
Adenovirus fibers from most serotypes bind the D1 domain of coxsackie and, adenovirus receptor (CAR), although the binding residues are not strictly, conserved. To understand this further, we determined the crystal, structures of canine adenovirus serotype 2 (CAV-2) and the human, adenovirus serotype 37 (HAd37) in complex with human CAR D1 at 2.3 and, 1.5A resolution, respectively. Structure comparison with the HAd12 fiber, head-CAR D1 complex showed that the overall topology of the interaction is, conserved but that the interfaces differ in number and identity of, interacting residues, shape complementarity, and degree of conformational, adaptation. Using surface plasmon resonance, we characterized the binding, affinity to CAR D1 of wild type and mutant CAV-2 and HAd37 fiber heads. We, ... [(full description)]
About this Structure
2J12 is a [Protein complex] structure of sequences from [Homo sapiens] and [Human adenovirus type 49] with CA as [ligand]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
Structural and mutational analysis of human Ad37 and canine adenovirus 2 fiber heads in complex with the D1 domain of coxsackie and adenovirus receptor., Seiradake E, Lortat-Jacob H, Billet O, Kremer EJ, Cusack S, J Biol Chem. 2006 Nov 3;281(44):33704-16. Epub 2006 Aug 21. PMID:16923808
Page seeded by OCA on Tue Oct 30 11:26:39 2007
Categories: Homo sapiens | Human adenovirus type 49 | Protein complex | Billet, O. | Cusac, S. | Kremer, E.J. | Lortat-Jacob, H. | Seiradake, E. | CA | Ad37 | Adenovirus | Alternative splicing | Car | Cell adhesion | Complex | Coxsackievirus | Glycoprotein | Had37 | Host-virus interaction | Immunoglobulin domain | Lipoprotein | Membrane | Palmitate | Phosphorylation | Receptor | Tight junction | Transmembrane | Viral protein/receptor complex | X-ray
