From Proteopedia
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| - | <table style="background: #D1FFE7; border:1px solid #94FFC8" cellspacing="5px" cellpadding="10px">
| + | {{Featured article}} |
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| - | <div style="font-size:120%" align="left">Featured from May 2, 2009 - October 18, 2009</div>
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| - | <applet size='300' frame='false' scene='Avian_Influenza_Neuraminidase,_Tamiflu_and_Relenza/2hu4_tetramer/3' />
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| - | </td>
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| - | <div style="font-size:130%; line-height:2.0em"><span style="color:green" align="center">Green</span> links change the 3D image!
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| - | Click and drag on the molecule!</div>
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| - | <div style="font-size:200%; line-height:2.0em">[[Avian_Influenza_Neuraminidase%2C_Tamiflu_and_Relenza|Swine Flu, Neuraminidase & Tamiflu]]</div>
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| - | [[Avian_Influenza_Neuraminidase%2C_Tamiflu_and_Relenza#Influenza Virus Neuraminidase|H5N1]] bird flu has seemed a likely pandemic threat for decades, but the first new influenza virus to emerge as an imminent pandemic threat in the 21<sup>st</sup> century is [[Avian_Influenza_Neuraminidase%2C_Tamiflu_and_Relenza#Influenza Virus Neuraminidase|H1N1]] swine flu.
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| - | The drug oseltamivir (Tamiflu®) inhibits flu neuraminidase, a component necessary for virus spread, in susceptible flu strains. Luckily H1N1 swine flu is susceptible (at least in early May, 2009).
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| - | The development of oseltamivir was guided, in part, by crystallographically determined structures of flu neuraminidase. Neuraminidase is a homotetramer, shown with oseltamivir bound (<scene name='Avian_Influenza_Neuraminidase,_Tamiflu_and_Relenza/2hu4_tetramer/3'>restore initial scene</scene>). Here is <scene name='User:Eric_Martz/Sandbox_0/2hu4_tetramer/1'>one catalytic site</scene>. Oseltamivir was designed to fit [[Avian_Influenza_Neuraminidase%2C_Tamiflu_and_Relenza#Influenza Virus Neuraminidase|N2/N9]] (neuraminidases from other strains of flu). Serendipitously, it also fits N1, doing so by <scene name='<scene name='User:Eric_Martz/Sandbox_0/Morph_2hty_to_2hu4/4'>pulling one side of the binding site against itself</scene> ([[Induced fit|induced fit]]). The most common mutation in N1 that confers resistance to oseltamivir is H274Y. The mutant tyrosine prevents oseltamivir from fitting, but still allows <scene name='User:Eric_Martz/Sandbox_6/3ckz_relenza_tyr274/2'>zanamivir (Relenza) to bind</scene>. [[Avian_Influenza_Neuraminidase%2C_Tamiflu_and_Relenza|Read more...]].
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| - | <div align="right">[[Proteopedia:Featured article archives|Earlier featured articles...]]</div>
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| - | </td>
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| - | </tr>
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| - | </table>
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Revision as of 03:27, 30 December 2010
Green links change the 3D image!
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