3m36

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Revision as of 03:17, 2 January 2011

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Template:STRUCTURE 3m36

Factor XA in complex with the inhibitor 1-[3-(aminomethyl)phenyl]-N-[3-fluoro-2'-(methylsulfonyl)biphenyl-4-yl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide (DPC423)

Template:ABSTRACT PUBMED 14640539

About this Structure

3m36 is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

• Pruitt JR, Pinto DJ, Galemmo RA Jr, Alexander RS, Rossi KA, Wells BL, Drummond S, Bostrom LL, Burdick D, Bruckner R, Chen H, Smallwood A, Wong PC, Wright MR, Bai S, Luettgen JM, Knabb RM, Lam PY, Wexler RR. Discovery of 1-(2-aminomethylphenyl)-3-trifluoromethyl-N- [3-fluoro-2'-(aminosulfonyl)[1,1'-biphenyl)]-4-yl]-1H-pyrazole-5-carboxyam ide (DPC602), a potent, selective, and orally bioavailable factor Xa inhibitor(1). J Med Chem. 2003 Dec 4;46(25):5298-315. PMID:14640539 doi:10.1021/jm030212h