2i03
From Proteopedia
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==About this Structure== | ==About this Structure== | ||
| - | + | [[2i03]] is a 4 chain structure of [[Dipeptidyl peptidase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I03 OCA]. | |
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| + | ==See Also== | ||
| + | *[[Dipeptidyl peptidase]] | ||
==Reference== | ==Reference== | ||
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[[Category: Madar, D J.]] | [[Category: Madar, D J.]] | ||
[[Category: Enzyme]] | [[Category: Enzyme]] | ||
| + | [[Category: Hydrolase]] | ||
[[Category: Serine peptidase]] | [[Category: Serine peptidase]] | ||
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| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 00:08:04 2009'' | ||
Revision as of 12:03, 3 January 2011
Contents |
Crystal structure of human dipeptidyl peptidase 4 (DPP IV) with potent alkynyl cyanopyrrolidine (ABT-279)
Template:ABSTRACT PUBMED 17034148
About this Structure
2i03 is a 4 chain structure of Dipeptidyl peptidase with sequence from Homo sapiens. Full crystallographic information is available from OCA.
See Also
Reference
- Madar DJ, Kopecka H, Pireh D, Yong H, Pei Z, Li X, Wiedeman PE, Djuric SW, Von Geldern TW, Fickes MG, Bhagavatula L, McDermott T, Wittenberger S, Richards SJ, Longenecker KL, Stewart KD, Lubben TH, Ballaron SJ, Stashko MA, Long MA, Wells H, Zinker BA, Mika AK, Beno DW, Kempf-Grote AJ, Polakowski J, Segreti J, Reinhart GA, Fryer RM, Sham HL, Trevillyan JM. Discovery of 2-[4-{{2-(2S,5R)-2-cyano-5-ethynyl-1-pyrrolidinyl]-2-oxoethyl]amino]- 4-methyl-1-piperidinyl]-4-pyridinecarboxylic acid (ABT-279): a very potent, selective, effective, and well-tolerated inhibitor of dipeptidyl peptidase-IV, useful for the treatment of diabetes. J Med Chem. 2006 Oct 19;49(21):6416-20. PMID:17034148 doi:10.1021/jm060777o
