1x70

(Difference between revisions)

Revision as of 12:06, 3 January 2011

1x70, resolution 2.10Å ()

Ligands:

, , ,

Gene:

DPP4, ADCP2, CD26 (Homo sapiens)

Activity:

Dipeptidyl-peptidase IV, with EC number 3.4.14.5

Structural annotation:
Resources:	CATH : 1X70A01, 1X70A02, 1X70B02, 1X70B01 InterPro : Ipr002469, Ipr002471, Ipr001375 Pfam : PF00930, PF00326 SCOP : d1x70a2, d1x70a1, d1x70b2, d1x70b1

Evolutionary conservation:

Toggle Conservation Colors:	Rows = identical sequences:
Further Information:	Caveats, Explanation, Complete Results at ConSurfDB

Resources:

FirstGlance, OCA, RCSB, PDBsum

Coordinates:

save as pdb, mmCIF, xml

1x70 is a 2 chain structure of Dipeptidyl peptidase with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Kim D, Wang L, Beconi M, Eiermann GJ, Fisher MH, He H, Hickey GJ, Kowalchick JE, Leiting B, Lyons K, Marsilio F, McCann ME, Patel RA, Petrov A, Scapin G, Patel SB, Roy RS, Wu JK, Wyvratt MJ, Zhang BB, Zhu L, Thornberry NA, Weber AE. (2R)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin -7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine: a potent, orally active dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes. J Med Chem. 2005 Jan 13;48(1):141-51. PMID:15634008 doi:10.1021/jm0493156

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 ==About this Structure==
-[[1x70]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X70 OCA].
+[[1x70]] is a 2 chain structure of [[Dipeptidyl peptidase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X70 OCA].
 ==See Also==
+*[[Dipeptidyl peptidase]]
 *[[Sitagliptin]]