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2iut

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(New page: 200px<br /> <applet load="2iut" size="450" color="white" frame="true" align="right" spinBox="true" caption="2iut, resolution 2.25&Aring;" /> '''P. AERUGINOSA FTSK ...)
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==About this Structure==
==About this Structure==
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2IUT is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]] with MG and ATG as [[http://en.wikipedia.org/wiki/ligands ligands]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2IUT OCA]].
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2IUT is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]] with MG and ATG as [[http://en.wikipedia.org/wiki/ligands ligands]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2IUT OCA]].
==Reference==
==Reference==
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[[Category: transmembrane]]
[[Category: transmembrane]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Oct 29 17:58:43 2007''
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 11:29:16 2007''

Revision as of 09:24, 30 October 2007

Image:2iut.gif

2iut, resolution 2.25Å

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P. AERUGINOSA FTSK MOTOR DOMAIN, DIMERIC

Overview

FtsK is a DNA translocase that coordinates chromosome segregation and cell, division in bacteria. In addition to its role as activator of XerCD, site-specific recombination, FtsK can translocate double-stranded DNA, (dsDNA) rapidly and directionally and reverse direction. We present, crystal structures of the FtsK motor domain monomer, showing that it has a, RecA-like core, the FtsK hexamer, and also showing that it is a ring with, a large central annulus and a dodecamer consisting of two hexamers, head, to head. Electron microscopy (EM) demonstrates the DNA-dependent existence, of hexamers in solution and shows that duplex DNA passes through the, middle of each ring. Comparison of FtsK monomer structures from two, different crystal forms highlights a conformational change that we ... [(full description)]

About this Structure

2IUT is a [Single protein] structure of sequence from [Pseudomonas aeruginosa] with MG and ATG as [ligands]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].

Reference

Double-stranded DNA translocation: structure and mechanism of hexameric FtsK., Massey TH, Mercogliano CP, Yates J, Sherratt DJ, Lowe J, Mol Cell. 2006 Aug;23(4):457-69. PMID:16916635

Page seeded by OCA on Tue Oct 30 11:29:16 2007

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