2iuz

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(New page: 200px<br /> <applet load="2iuz" size="450" color="white" frame="true" align="right" spinBox="true" caption="2iuz, resolution 1.95&Aring;" /> '''CRYSTAL STRUCTURE O...)
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==About this Structure==
==About this Structure==
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2IUZ is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Aspergillus_fumigatus Aspergillus fumigatus]] with SO4 and D1H as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.14 3.2.1.14]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2IUZ OCA]].
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2IUZ is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Aspergillus_fumigatus Aspergillus fumigatus]] with SO4 and D1H as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/Chitinase Chitinase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.14 3.2.1.14]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2IUZ OCA]].
==Reference==
==Reference==
Screening-based discovery and structural dissection of a novel family 18 chitinase inhibitor., Schuttelkopf AW, Andersen OA, Rao FV, Allwood M, Lloyd C, Eggleston IM, van Aalten DM, J Biol Chem. 2006 Sep 15;281(37):27278-85. Epub 2006 Jul 14. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16844689 16844689]
Screening-based discovery and structural dissection of a novel family 18 chitinase inhibitor., Schuttelkopf AW, Andersen OA, Rao FV, Allwood M, Lloyd C, Eggleston IM, van Aalten DM, J Biol Chem. 2006 Sep 15;281(37):27278-85. Epub 2006 Jul 14. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16844689 16844689]
[[Category: Aspergillus fumigatus]]
[[Category: Aspergillus fumigatus]]
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[[Category: Chitinase]]
[[Category: Single protein]]
[[Category: Single protein]]
[[Category: Aalten, D.M.F.Van.]]
[[Category: Aalten, D.M.F.Van.]]
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[[Category: hydrolase]]
[[Category: hydrolase]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Oct 29 17:59:24 2007''
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 11:29:52 2007''

Revision as of 09:25, 30 October 2007


2iuz, resolution 1.95Å

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CRYSTAL STRUCTURE OF ASPERGILLUS FUMIGATUS CHITINASE B1 IN COMPLEX WITH C2-DICAFFEINE

Overview

Family 18 chitinases play key roles in the life cycles of a variety of, organisms ranging from bacteria to man. Very recently it has been shown, that one of the mammalian chitinases is highly overexpressed in the, asthmatic lung and contributes to the pathogenic process through, recruitment of inflammatory cells. Although several potent natural product, chitinase inhibitors have been identified, their chemotherapeutic, potential or their use as cell biological tools is limited due to their, size, complex chemistry, and limited availability. We describe a virtual, screening-based approach to identification of a novel, purine-based, chitinase inhibitor. This inhibitor acts in the low micromolar, (Ki=2.8+/-0.2 microM) range in a competitive mode. Dissection of the, binding mode by x-ray ... [(full description)]

About this Structure

2IUZ is a [Single protein] structure of sequence from [Aspergillus fumigatus] with SO4 and D1H as [ligands]. Active as [Chitinase], with EC number [3.2.1.14]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].

Reference

Screening-based discovery and structural dissection of a novel family 18 chitinase inhibitor., Schuttelkopf AW, Andersen OA, Rao FV, Allwood M, Lloyd C, Eggleston IM, van Aalten DM, J Biol Chem. 2006 Sep 15;281(37):27278-85. Epub 2006 Jul 14. PMID:16844689

Page seeded by OCA on Tue Oct 30 11:29:52 2007

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