2iup
From Proteopedia
(New page: 200px<br /> <applet load="2iup" size="450" color="white" frame="true" align="right" spinBox="true" caption="2iup, resolution 1.80Å" /> '''CRYSTAL STRUCTURE O...) |
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==About this Structure== | ==About this Structure== | ||
| - | 2IUP is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Alcaligenes_faecalis Alcaligenes faecalis]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.4.99.4 1.4.99.4]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2IUP OCA]]. | + | 2IUP is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Alcaligenes_faecalis Alcaligenes faecalis]]. Active as [[http://en.wikipedia.org/wiki/Aralkylamine_dehydrogenase Aralkylamine dehydrogenase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.4.99.4 1.4.99.4]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2IUP OCA]]. |
==Reference== | ==Reference== | ||
Atomic level insight into the oxidative half-reaction of aromatic amine dehydrogenase., Roujeinikova A, Scrutton NS, Leys D, J Biol Chem. 2006 Dec 29;281(52):40264-72. Epub 2006 Sep 27. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17005560 17005560] | Atomic level insight into the oxidative half-reaction of aromatic amine dehydrogenase., Roujeinikova A, Scrutton NS, Leys D, J Biol Chem. 2006 Dec 29;281(52):40264-72. Epub 2006 Sep 27. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17005560 17005560] | ||
[[Category: Alcaligenes faecalis]] | [[Category: Alcaligenes faecalis]] | ||
| + | [[Category: Aralkylamine dehydrogenase]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Leys, D.]] | [[Category: Leys, D.]] | ||
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[[Category: oxidoreductase]] | [[Category: oxidoreductase]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 11:30:32 2007'' |
Revision as of 09:25, 30 October 2007
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CRYSTAL STRUCTURE OF DITHIONITE-REDUCED AROMATIC AMINE DEHYDROGENASE (AADH) FROM ALCALIGENES FAECALIS
Overview
The quinoprotein aromatic amine dehydrogenase (AADH) uses a covalently, bound tryptophan tryptophylquinone (TTQ) cofactor to oxidatively deaminate, primary aromatic amines. Recent crystal structures have provided insight, into the reductive half-reaction. In contrast, no atomic details are, available for the oxidative half-reaction. The TTQ O7 hydroxyl group is, protonated during reduction, but it is unclear how this proton can be, removed during the oxidative half-reaction. Furthermore, compared with the, electron transfer from the N-quinol form, electron transfer from the, non-physiological O-quinol form to azurin is significantly slower. Here we, report crystal structures of the O-quinol, N-quinol, and N-semiquinone, forms of AADH. A comparison of oxidized and substrate reduced AADH ... [(full description)]
About this Structure
2IUP is a [Single protein] structure of sequence from [Alcaligenes faecalis]. Active as [Aralkylamine dehydrogenase], with EC number [1.4.99.4]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
Atomic level insight into the oxidative half-reaction of aromatic amine dehydrogenase., Roujeinikova A, Scrutton NS, Leys D, J Biol Chem. 2006 Dec 29;281(52):40264-72. Epub 2006 Sep 27. PMID:17005560
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