1hi8
From Proteopedia
(New page: 200px<br /> <applet load="1hi8" size="450" color="white" frame="true" align="right" spinBox="true" caption="1hi8, resolution 2.5Å" /> '''RNA DEPENDENT RNA PO...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1HI8 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Bacteriophage_phi-6 Bacteriophage phi-6]] with MG as [[http://en.wikipedia.org/wiki/ligand ligand]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1HI8 OCA]]. | + | 1HI8 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Bacteriophage_phi-6 Bacteriophage phi-6]] with MG as [[http://en.wikipedia.org/wiki/ligand ligand]]. Structure known Active Sites: CA1, CA2, MG1 and MG2. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1HI8 OCA]]. |
==Reference== | ==Reference== | ||
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[[Category: viral polymerase]] | [[Category: viral polymerase]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 11:31:12 2007'' |
Revision as of 09:26, 30 October 2007
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RNA DEPENDENT RNA POLYMERASE FROM DSRNA BACTERIOPHAGE PHI6
Overview
In most RNA viruses, genome replication and transcription are catalysed by, a viral RNA-dependent RNA polymerase. Double-stranded RNA viruses perform, these operations in a capsid (the polymerase complex), using an enzyme, that can read both single- and double-stranded RNA. Structures have been, solved for such viral capsids, but they do not resolve the polymerase, subunits in any detail. Here we show that the 2 A resolution X-ray, structure of the active polymerase subunit from the double-stranded RNA, bacteriophage straight phi6 is highly similar to that of the polymerase of, hepatitis C virus, providing an evolutionary link between double-stranded, RNA viruses and flaviviruses. By crystal soaking and co-crystallization, we determined a number of other structures, including complexes ... [(full description)]
About this Structure
1HI8 is a [Single protein] structure of sequence from [Bacteriophage phi-6] with MG as [ligand]. Structure known Active Sites: CA1, CA2, MG1 and MG2. Full crystallographic information is available from [OCA].
Reference
A mechanism for initiating RNA-dependent RNA polymerization., Butcher SJ, Grimes JM, Makeyev EV, Bamford DH, Stuart DI, Nature. 2001 Mar 8;410(6825):235-40. PMID:11242087
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