2d5v
From Proteopedia
(New page: 200px<br /><applet load="2d5v" size="450" color="white" frame="true" align="right" spinBox="true" caption="2d5v, resolution 2.0Å" /> '''Crystal structure of ...) |
|||
| Line 1: | Line 1: | ||
| - | [[Image:2d5v.gif|left|200px]]<br /><applet load="2d5v" size=" | + | [[Image:2d5v.gif|left|200px]]<br /><applet load="2d5v" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="2d5v, resolution 2.0Å" /> | caption="2d5v, resolution 2.0Å" /> | ||
'''Crystal structure of HNF-6alpha DNA-binding domain in complex with the TTR promoter'''<br /> | '''Crystal structure of HNF-6alpha DNA-binding domain in complex with the TTR promoter'''<br /> | ||
| Line 7: | Line 7: | ||
==About this Structure== | ==About this Structure== | ||
| - | 2D5V is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] with ACT and GOL as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http:// | + | 2D5V is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] with <scene name='pdbligand=ACT:'>ACT</scene> and <scene name='pdbligand=GOL:'>GOL</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2D5V OCA]. |
==Reference== | ==Reference== | ||
| Line 22: | Line 22: | ||
[[Category: transcription factor]] | [[Category: transcription factor]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 23 13:31:46 2008'' |
Revision as of 11:31, 23 January 2008
|
Crystal structure of HNF-6alpha DNA-binding domain in complex with the TTR promoter
Overview
Hepatocyte nuclear factor-6 (HNF-6), a liver-enriched transcription, factor, controls the development of various tissues, such as the pancreas, and liver, and regulates the expression of several hepatic genes. This, protein belongs to the ONECUT class of homeodomain proteins and contains a, bipartite DNA-binding domain composed of a single cut domain and a, characteristic homeodomain. This transcription factor has two distinct, modes of DNA binding and transcriptional activation that use different, coactivators depending on the target gene. The crystal structure of the, bipartite DNA-binding domain of HNF-6alpha complexed with the, HNF-6-binding site of the TTR promoter revealed the DNA recognition, mechanism of this protein. Comparing our structure with the DNA-free, structure of HNF-6 or the structure of Oct-1, we discuss characteristic, features associated with DNA binding and the structural basis for the dual, mode of action of this protein, and we suggest a strategy for variability, of transcriptional activation of the target gene.
About this Structure
2D5V is a Single protein structure of sequence from Rattus norvegicus with and as ligands. Full crystallographic information is available from OCA.
Reference
DNA recognition mechanism of the ONECUT homeodomain of transcription factor HNF-6., Iyaguchi D, Yao M, Watanabe N, Nishihira J, Tanaka I, Structure. 2007 Jan;15(1):75-83. PMID:17223534
Page seeded by OCA on Wed Jan 23 13:31:46 2008
