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Cytochrome P450

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{{STRUCTURE_2f9q| PDB=2f9q | SIZE=300| SCENE=Cytochrome_P450/Cv/1 |right|CAPTION=Cytochrome P450 [[2f9q]] }}
{{STRUCTURE_2f9q| PDB=2f9q | SIZE=300| SCENE=Cytochrome_P450/Cv/1 |right|CAPTION=Cytochrome P450 [[2f9q]] }}
-
Cytochrome P450 (CYP) catalyzes the oxidation of organic substances like lipids. The CYP contains a heme cofactor. The protein is numbered by its gene. CYP-cam catalyzes the hydroxylation of camphor. P450nor is a Nitric Oxide Reductase CYP. The images at the left and at the right correspond to one representative CYP, ''i.e.'' the crystal structure of human CYP2 ([[2f9q]]).
+
Cytochrome P450 (P450) catalyzes the oxidation of organic substances like lipids. catalyzes the oxidation of organic substances like lipids. The P450 contains a heme cofactor. The protein is numbered by its gene. P450cam, also known as camphor 5-monooxygenase, catalyzes the hydroxylation of camphor. P450nor is a Nitric Oxide Reductase P450. P450epoK converts epothilone D to epothilone B. P450cin monooxygenates 1,8-cineole which is similar to camphor. The images at the left and at the right correspond to one representative P450, ''i.e.'' the crystal structure of human P4502 ([[2f9q]]).
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== 3D Structures of Cytochrome P450 ==
== 3D Structures of Cytochrome P450 ==
-
 
+
=== human P4501 family ===
-
 
+
-
=== CYP/P450 reductase ===
+
-
 
+
-
[[3kx3]], [[3kx4]], [[3kx5]], [[3hf2]], [[3dgi]], [[3cbd]], [[2nnb]], [[1zo4]], [[2yqo]], [[2yqp]], [[1smi]], [[1p0v]], [[1p0w]], [[1p0x]], [[1jme]] – BmCYP102A1/P450 reductase (mutant) – ''Bacilus megaterium''<br />
+
-
[[1zo9]] - BmCYP102A1/P450 reductase+N-palmitoylmethionine<br />
+
-
[[1zoa]], [[1jpz]] - BmCYP102A1/P450 reductase (mutant)+N-palmitoylglycine<br />
+
-
[[1smj]] - BmCYP102A1/P450 reductase (mutant)+N-palmitoleate
+
-
 
+
-
 
+
-
=== human CYP1 family ===
+
-
[[2hi4]] – hCYP1A2+naphthoflavone - human
+
[[2hi4]] – hP4501A2+naphthoflavone - human<br />
-
 
+
[[3pm0]] - hP4501B1+naphthoflavone<br />
-
=== human CYP2 family ===
+
=== human P4502 family ===
-
[[3gph]], [[3koh]], [[3lc4]] – hCYP2E1 fragment +imidazole derivative<br />
+
[[3gph]], [[3koh]], [[3lc4]] – hP4502E1 fragment +imidazole derivative<br />
-
[[3e6i]] – hCYP2E1 fragment+indazole<br />
+
[[3e6i]] – hP4502E1 fragment+indazole<br />
-
[[3ebs]] – hCYP2A6 (mutant)+phenacetin<br />
+
[[3ebs]] – hP4502A6 (mutant)+phenacetin<br />
-
[[2fdu]], [[2fdv]], [[2fdw]], [[2fdy]] - hCYP2A6+pyridine derivative<br />
+
[[2fdu]], [[2fdv]], [[2fdw]], [[2fdy]] - hP4502A6+pyridine derivative<br />
-
[[3e4e]] – hCYP2E1 fragment+methylpyrazole<br />
+
[[1z10]] - hP4502A6 catalytic domain+coumarin<br />
-
[[3czh]], [[3dl9]], [[3c6g]] – hCYP2R1+vitamin D<br />
+
[[3e4e]] – hP4502E1 fragment+methylpyrazole<br />
-
[[2nnh]] – hCYP2C8+retinoic acid<br />
+
[[3czh]], [[3dl9]], [[3c6g]] – hP4502R1+vitamin D<br />
-
[[2nni]] - hCYP2C8+montelukast<br />
+
[[2nnh]] – hP4502C8+retinoic acid<br />
-
[[2nnj]] - hCYP2C8+felodipine<br />
+
[[2nni]] - hP4502C8+montelukast<br />
-
[[1pq2]] - hCYP2C8<br />
+
[[2nnj]] - hP4502C8+felodipine<br />
-
[[1og2]], [[1og5]] – hCYP2C9 (mutant)<br />
+
[[1pq2]] - hP4502C8<br />
-
[[1r9o]] – hCYP2C9 (mutant)+flurbiprofen<br />
+
[[1og2]], [[1og5]] – hP4502C9 (mutant)<br />
-
[[2pg5]], [[2pg6]], [[2pg7]] – hCYP2A6 (mutant)<br />
+
[[1r9o]] – hP4502C9 (mutant)+flurbiprofen<br />
-
[[2p85]] – hCYP2A13 (mutant)+indole<br />
+
[[2pg5]], [[2pg6]], [[2pg7]] – hP4502A6 (mutant)<br />
-
[[3ibd]] – hCYP2B6 (mutant)+4-(4-chlorophenyl)imidazole<br />
+
[[2p85]] – hP4502A13 (mutant)+indole<br />
-
[[2f9q]] – hCYP2D6<br />
+
[[3ibd]] – hP4502B6 (mutant)+4-(4-chlorophenyl)imidazole<br />
-
[[2z10]] – hCYP2A6+coumarin<br />
+
[[2f9q]] – hP4502D6<br />
-
[[1z11]] - hCYP2A6+methoxalen
+
[[2z10]] – hP4502A6+coumarin<br />
 +
[[1z11]] - hP4502A6+methoxalen
-
=== human CYP3 family ===
+
=== human P4503 family ===
-
[[2v0m]] – hCYP3A4+ketoconazole<br />
+
[[2v0m]] – hP4503A4+ketoconazole<br />
-
[[2j0d]] - hCYP3A4+erythromycin<br />
+
[[2j0d]] - hP4503A4+erythromycin<br />
-
[[1tqn]], [[1w0e]], [[1w0f]], [[1w0g]] – hCYP3A4
+
[[3nxu]] - hP4503A4+ritonavir<br />
 +
[[1tqn]], [[1w0e]], [[1w0f]], [[1w0g]] – hP4503A4<br />
-
=== human CYP7 family ===
+
=== human P4507 family ===
-
[[3dax]] – hCYP7A1
+
[[3dax]] – hP4507A1
-
=== human CYP19 family ===
+
=== human P45019 family ===
-
[[3eqm]] - hCYP19A1+androstenedione
+
[[3eqm]] - hP45019A1+androstenedione
-
=== human CYP46 family ===
+
=== human P45046 family ===
-
[[2q9f]] – hCYP46A1+cholesterol<br />
+
[[2q9f]] – hP45046A1+cholesterol<br />
-
[[2q9d]] - hCYP46A1<br />
+
[[2q9d]], [[2q9g]] - hP45046A1<br />
-
[[2vn0]] – hCYP105A1+troglitazone<br />
+
[[2vn0]] – hP450105A1+troglitazone<br />
-
[[2zby]] - hCYP105A1 (mutant)
+
[[2zby]] - hP450105A1 (mutant)
-
=== CYP from ''Mycobacterium tuberculosis'' ===
+
=== P450 from ''Mycobacterium tuberculosis'' ===
-
[[2vku]], [[1h5z]] – MtCYP51 - ''Mycobacterium tuberculosis''<br />
+
[[2vku]], [[1h5z]] – MtP45051 - ''Mycobacterium tuberculosis''<br />
-
[[2ci0]], [[2cib]], [[1u13]] - MtCYP51 (mutant)<br />
+
[[2ci0]], [[2cib]], [[1u13]] - MtP45051 (mutant)<br />
-
[[1x8v]] - MtCYP51 (mutant)+estriol<br />
+
[[1x8v]] - MtP45051 (mutant)+estriol<br />
-
[[1ea1]] - MtCYP51 (mutant)+ fluconazole<br />
+
[[1ea1]] - MtP45051 (mutant)+ fluconazole<br />
-
[[1e9x]] - MtCYP51 (mutant)+ phenylimidazole<br />
+
[[1e9x]] - MtP45051 (mutant)+ phenylimidazole<br />
-
[[3cxv]], [[3cxx]], [[3cxy]], [[3cxz]], [[3cy0]], [[3cy1]] - MtCYP121 (mutant)<br />
+
[[3cxv]], [[3cxx]], [[3cxy]], [[3cxz]], [[3cy0]], [[3cy1]] - MtP450121 (mutant)<br />
-
[[3g5f]], [[3g5h]], [[2ij5]], [[1n40]] – MtCYP121<br />
+
[[3g5f]], [[3g5h]], [[2ij5]], [[1n40]] – MtP450121<br />
-
[[2ij7]] - MtCYP121+fluconazole<br />
+
[[2ij7]] - MtP450121+fluconazole<br />
-
[[1n4g]] - MtCYP121+iodopyrazole<br />
+
[[1n4g]] - MtP450121+iodopyrazole<br />
-
[[3ivi]], [[3iw0]] – MtCYP125 <br />
+
[[3ivi]], [[3iw0]] – MtP450125 <br />
-
[[3iw1]] - MtCYP125+androstenedione<br />
+
[[3iw1]] - MtP450125+androstenedione<br />
-
[[3iw2]] - MtCYP125+econazole<br />
+
[[3iw2]] - MtP450125+econazole<br />
-
[[2uvn]] - MtCYP130+econazole<br />
+
[[2uvn]] - MtP450130+econazole<br />
-
[[2wgy]] – MtCYP130 (mutant)<br />
+
[[2wgy]] – MtP450130 (mutant)<br />
-
[[2w09]], [[2w0b]], [[2w0a]] - MtCYP130 (mutant)+pyridine inhibitor<br />
+
[[2w09]], [[2w0b]], [[2w0a]] - MtP450130 (mutant)+pyridine inhibitor<br />
-
[[2uuq]] – MtCYP130
+
[[2uuq]] – MtP450130
-
=== CYP-cam ===
+
=== P450cam ===
-
[[2qbl]], [[2qbm]], [[2qbn]], [[2gqx]], [[2gr6]], [[2frz]], [[2h7s]], [[6cp4]], [[2cp4]], [[3cp4]], [[4cp4]] – PpCYP-cam (mutant) – ''Pseudomona putida''<br />
+
[[2qbl]], [[2qbm]], [[2qbn]], [[2gqx]], [[2gr6]], [[2frz]], [[2h7s]], [[6cp4]], [[2cp4]], [[3cp4]], [[4cp4]], [[1c8j]], [[1geb]], [[2a1o]] – PpP450cam(mutant) – ''Pseudomona putida''<br />
-
[[1dz4]], [[1dz8]], [[1dz6]], [[1dz9]], [[5cp4]], [[1phc]], [[2cpp]] - PpCYP-cam<br />
+
[[1dz4]], [[1dz8]], [[1dz6]], [[1dz9]], [[5cp4]], [[1phc]], [[2cpp]], [[1yrc]], [[1yrd]], [[3l61]], [[3l62]], [[3l63]] - PpP450cam<br />
-
[[2qbo]] - PpCYP-cam (mutant)+cyanide<br />
+
[[2qbo]] - PpP450cam (mutant)+cyanide<br />
-
[[1qmq]] - PpCYP-cam (mutant)+Ru substrate<br />
+
[[1qmq]] - PpP450cam (mutant)+Ru substrate<br />
-
[[2h7q]] - PpCYP-cam+imidazole<br />
+
[[2h7q]] - PpP450cam+imidazole<br />
-
[[1cp4]] - PpCYP-cam+benzene<br />
+
[[1cp4]] - PpP450cam+benzene<br />
-
[[1akd]] - PpCYP-cam+1S-camphor<br />
+
[[1akd]], [[1iwi]], [[1noo]], [[7cpp]], [[8cpp]], [[2zwt]], [[2zwu]] - PpP450cam+1S-camphor derivative<br />
-
[[2fe6]], [[2fer]], [[2feu]] - PpCYP-cam+Mn protoporphyrin IX<br />
+
[[1iwj]], [[1iwk]], [[2zuh]], [[2zui]], [[2zuj]], [[3fwf]], [[3fwg]], [[3fwi]], [[3fwj]] - PpP450cam (mutant)+1Scamphor<br />
-
[[1uyu]] - PpCYP-cam + Xe<br />
+
[[2fe6]], [[2fer]], [[2feu]] - PpP450cam+Mn protoporphyrin IX<br />
-
[[1o76]] - PpCYP-cam +cyanide<br />
+
[[1uyu]] - PpP450cam+ Xe<br />
-
[[4cpp]] - PpCYP-cam+adamantine<br />
+
[[1o76]] - PpP450cam+cyanide<br />
-
[[5cpp]] - PpCYP-cam+adamantanone<br />
+
[[4cpp]] - PpP450cam+adamantine<br />
-
[[6cpp]] - PpCYP-cam+camphene<br />
+
[[5cpp]] - PpP450cam+adamantanone<br />
-
[[7cpp]] - PpCYP-cam+norcamphor<br />
+
[[6cpp]] - PpP450cam+camphene<br />
-
[[8cpp]] - PpCYP-cam+thiocamphor<br />
+
[[1p2y]], [[1p7r]] - PpP450cam+nicotine<br />
-
[[3cpp]] - PpCYP-cam+CO<br />
+
[[1re9]], [[1rf9]] - PpP450cam +fluorescent probe<br />
-
[[1pha]], [[1phb]], [[1phd]], [[1phe]], [[1phf]], [[1phg]] - PpCYP-cam+imidazole derivative<br />
+
[[2z97]], [[2zaw]], [[2zax]] - PpP450cam+methyl depropionated hemin<br />
-
[[1gek]], [[1gem]] - PpCYP-cam +N-butyl-isocyanide<br />
+
[[3cpp]] - PpP450cam+CO<br />
-
[[1lwl]] - PpCYP-cam +fluorescent probe<br />
+
[[1pha]], [[1phb]], [[1phd]], [[1phe]], [[1phf]], [[1phg]] - PpP450cam+imidazole derivative<br />
-
[[2h7r]] - PpCYP-cam (mutant)+imidazole<br />
+
[[1gek]], [[1gem]] - PpP450cam+N-butyl-isocyanide<br />
-
[[1k2o]] - PpCYP-cam (mutant)+pyridine derivative<br />
+
[[1lwl]] - PpP450cam+fluorescent probe<br />
-
[[1gjm]] - PpCYP-cam (mutant)+sulphydryl reagent<br />
+
[[2h7r]] - PpP450cam (mutant)+imidazole<br />
-
[[2a1m]], [[2a1n]], [[2a10]] - PpCYP-cam (mutant)+ferrous dioxygen<br />
+
[[1k2o]] - PpP450cam (mutant)+pyridine derivative<br />
-
[[1t85]], [[1t86]], [[1t87]], [[1t88]] - PpCYP-cam (mutant)+ferrous CO
+
[[1gjm]] - PpP450cam (mutant)+sulphydryl reagent<br />
 +
[[2a1m]], [[2a1n]], [[2a10]] - PpP450cam (mutant)+ferrous dioxygen<br />
 +
[[1t85]], [[1t86]], [[1t87]], [[1t88]] - PpP450cam (mutant)+ferrous CO<br />
 +
[[1j51]] - PpP450cam (mutant)+trichlorobenzene<br />
 +
[[1mpw]] - PpP450cam (mutant)+trimethylbicycloheptene<br />
 +
[[3oia]], [[3ol5]], [[3p6m]], [[3p6n]], [[3p6o]], [[3p6p]], [[3poq]], [[3por]], [[3pos]], [[3pot]], [[3pou]], [[3pov]], [[3pow]], [[3pox]] - PpP450cam (mutant)+substrate analog<br />
Line 123: Line 120:
[[1cl6]], [[1rom]] – FoP450nor - ''Fusarium oxysporum''<br />
[[1cl6]], [[1rom]] – FoP450nor - ''Fusarium oxysporum''<br />
[[2rom]] - FoP450nor+CO<br />
[[2rom]] - FoP450nor+CO<br />
-
[[1cmj]], [[1cmn]] - FoP450nor (mutant)<br />
+
[[1cmj]], [[1cmn]], [[1ehg]] - FoP450nor (mutant)<br />
[[1xqd]] – FoP450nor+pyridinealdehyde adenine<br />
[[1xqd]] – FoP450nor+pyridinealdehyde adenine<br />
-
[[1jfb]], [[1jfc]], [[1ged]] - FoP450nor<br />
+
[[1jfb]], [[1jfc]], [[1ged]], [[1ehe]] - FoP450nor<br />
[[1gej]], [[1gei]] - FoP450nor+N-butyl-isocyanide<br />
[[1gej]], [[1gei]] - FoP450nor+N-butyl-isocyanide<br />
[[1ulw]] - FoP450nor (mutant)
[[1ulw]] - FoP450nor (mutant)
 +
===P450epoK===
 +
 +
[[1pfk]] – P450epoK+epothilone D – ''Sorangium cellulosum''
 +
 +
===P450cin===
 +
[[3bdz]], [[3be0]] – P450cin – ''Citrobacter braakii''
-
=== rabbit CYP ===
+
=== rabbit P450 ===
-
[[2bdm]] – rCYP2B4 – rabbit<br />
+
[[2bdm]] – rP4502B4 – rabbit<br />
-
[[1po5]] - rCYP2B4 (mutant)<br />
+
[[1po5]], [[3mvr]] - rP4502B4 (mutant)<br />
-
[[1suo]] - rCYP2B4 (mutant)+imidazole<br />
+
[[1suo]] - rP4502B4 (mutant)+imidazole<br />
-
[[1dt6]] - rCYP2C5 (mutant)<br />
+
[[3kw4]], [[3me6]] - rP4502B4 (mutant)+anti-platelet drug<br />
-
[[1nr6]] – rCYP2C5+diclofenac<br />
+
[[1dt6]] - rP4502C5 (mutant)<br />
-
[[1n6b]] - rCYP2C5+sulfaphenazole
+
[[1nr6]] – rP4502C5+diclofenac<br />
 +
[[1n6b]] - rP4502C5+sulfaphenazole
=== Other CYPs ===
=== Other CYPs ===
-
[[1ued]] – AoCYP oxyC – ''Amycolatopsis orientalis''<br />
+
[[1ued]] – AoP450 oxyC – ''Amycolatopsis orientalis''<br />
-
[[1lfk]], [[1lg9]], [[1lgf]] - AoCYP oxyB<br />
+
[[1lfk]], [[1lg9]], [[1lgf]] - AoP450 oxyB<br />
-
[[1q5d]] – ScCYPEPOK+epothilone – ''Sorangium cellulosum''<br />
+
[[1q5d]] – ScP450EPOK+epothilone – ''Sorangium cellulosum''<br />
-
[[1q5e]] - ScCYPEPOK<br />
+
[[1q5e]] - ScP450EPOK<br />
-
[[1io8]] – SsCYP119 (mutant) – ''Sulfolobus solfataricus''<br />
+
[[1io8]] – SsP450119 (mutant) – ''Sulfolobus solfataricus''<br />
-
[[1io9]], [[1io7]], [[1f4u]] - SsCYP119<br />
+
[[1io9]], [[1io7]], [[1f4u]] - SsP450119<br />
-
[[1f4t]] - SsCYP119+ phenylimidazole<br />
+
[[1f4t]] - SsP450119+ phenylimidazole<br />
-
[[1cpt]] – CYP108 – ''Pseudomonas sp.''<br />
+
[[1cpt]] – P450108 – ''Pseudomonas sp.''<br />
-
[[2uwh]] - BmCYP102+palmitic acid<br />
+
[[2uwh]] - BmP450102+palmitic acid<br />
-
[[3ekb]], [[3ekd]], [[3ekf]], [[2ij3]], [[2ij4]] - BmCYP102 heme domain (mutant)<br />
+
[[3ekb]], [[3ekd]], [[3ekf]], [[2ij3]], [[2ij4]] - BmP450102 heme domain (mutant)<br />
-
[[2ij2]], [[2hpd]] - BmCYP102 heme domain<br />
+
[[2ij2]], [[2hpd]] - BmP450102 heme domain<br />
-
[[3ben]] - BmCYP102 + imidazole derivative<br />
+
[[3ben]] - BmP450102 + imidazole derivative<br />
-
[[2j1m]], [[2j4s]] - BmCYP102+DMSO<br />
+
[[2j1m]], [[2j4s]] - BmP450102+DMSO<br />
-
[[1bvy]], [[1bu7]] – BmCYP102A1 FMN domain<br />
+
[[1bvy]], [[1bu7]] – BmP450102A1 FMN domain<br />
-
[[1fag]] – BmCYP102A1+ palmitic acid<br />
+
[[1fag]] – BmP450102A1+ palmitic acid<br />
-
[[1fah]] – BmCYP102A1 (mutant)<br />
+
[[1fah]] – BmP450102A1 (mutant)<br />
-
[[2bmh]] - BmCYP102A1<br />
+
[[2bmh]] - BmP450102A1<br />
-
[[3aba]] – SaCYP105P1+filipin I – ''Streptomyces avermitilis''<br />
+
[[3aba]] – SaP450105P1+filipin I – ''Streptomyces avermitilis''<br />
-
[[3abb]] – SaCYP105D6<br />
+
[[3abb]] – SaP450105D6<br />
-
[[3e5j]], [[3e5l]] - SaCYP105P1 (mutant)<br />
+
[[3e5j]], [[3e5l]] - SaP450105P1 (mutant)<br />
-
[[3e5k]] - SaCYP105P1 (mutant)+4-phenylimidazole<br />
+
[[3e5k]] - SaP450105P1 (mutant)+4-phenylimidazole<br />
-
[[2whw]], [[2wi9]], [[2vz7]] – SvCYP107L1 (mutant) – ''Streptomyces venezuelae''<br />
+
[[2whw]], [[2wi9]], [[2vz7]] – SvP450107L1 (mutant) – ''Streptomyces venezuelae''<br />
-
[[2vzm]] – SvCYP107L1 (mutant)+narbomycin<br />
+
[[2vzm]] – SvP450107L1 (mutant)+narbomycin<br />
-
[[2c7x]] - SvCYP107L1+narbomycin<br />
+
[[2c7x]] - SvP450107L1+narbomycin<br />
-
[[2cd8]], [[2ca0]], [[2c6h]] – SvCYP107L1+YC-17<br />
+
[[2cd8]], [[2ca0]], [[2c6h]] – SvP450107L1+YC-17<br />
-
[[2bvj]] - SvCYP107L1<br />
+
[[2bvj]] - SvP450107L1<br />
-
[[2zqj]] – BsCYP152A1 – ''Bacillus subtilis''<br />
+
[[2zqj]] – BsP450152A1 – ''Bacillus subtilis''<br />
-
[[2zqx]] - BsCYP152A1+heptanoic acid<br />
+
[[2zqx]] - BsP450152A1+heptanoic acid<br />
-
[[1izo]] – BsCYP BS beta+ palmitoleic acid<br />
+
[[3nc3]], [[3nc5]], [[3nc6]], [[3nc7]] - BsP450134A1 (mutant)<br />
-
[[1jin]], [[1jip]] - SeCYP107A1+ ketoconazole - ''Saccharopolyspora erythraea''<br />
+
[[1izo]] – BsP450 BS beta+ palmitoleic acid<br />
-
[[1jio]], [[1oxa]] - SeCYP107A1+6DEB<br />
+
[[1jin]], [[1jip]] - SeP450107A1+ ketoconazole - ''Saccharopolyspora erythraea''<br />
-
[[1eup]] – SeCYP107A1+androstendione<br />
+
[[1jio]], [[1oxa]] - SeP450107A1+6DEB<br />
-
[[1egy]] - SeCYP107A1+aminophenanthrene<br />
+
[[1eup]] – SeP450107A1+androstendione<br />
-
[[2jjn]], [[2jjo]] - SeCYP113A1 (mutant)<br />
+
[[1egy]] - SeP450107A1+aminophenanthrene<br />
-
[[2jjp]] - SeCYP113A1 (mutant)+ketoconazole<br />
+
[[2jjn]], [[2jjo]] - SeP450113A1 (mutant)<br />
-
[[2vrv]] - SeCYP113A1 (mutant)+clotrimazole<br />
+
[[2jjp]] - SeP450113A1 (mutant)+ketoconazole<br />
-
[[3a1l]] – SsCYP245A1+dichlorochrompyrrolic acid – ''Streptomyces sp.''<br />
+
[[2vrv]] - SeP450113A1 (mutant)+clotrimazole<br />
-
[[2z3t]] - SsCYP245A1<br />
+
[[3a1l]] – SsP450245A1+dichlorochrompyrrolic acid – ''Streptomyces sp.''<br />
-
[[2z3u]] - SsCYP245A1+chromopyrrolic acid<br />
+
[[2z3t]] - SsP450245A1<br />
 +
[[2z3u]] - SsP450245A1+chromopyrrolic acid<br />
[[3g5n]], [[3g93]] – rCYP2B4 (mutant)+1-biphenyl-4-methyl-1H-imidazole – rabbit<br />
[[3g5n]], [[3g93]] – rCYP2B4 (mutant)+1-biphenyl-4-methyl-1H-imidazole – rabbit<br />
-
[[2q6n]] – rCYP2B4 (mutant)+chlorophenyl-imidazole<br />
+
[[2q6n]] – rP4502B4 (mutant)+chlorophenyl-imidazole<br />
-
[[3cv8]] – SgCYP105A1 (mutant) – ''Streptomyces griseolus''<br />
+
[[3cv8]] – SgP450105A1 (mutant) – ''Streptomyces griseolus''<br />
-
[[3cv9]], [[2zbz]] - SgCYP105A1 (mutant)+vitamin D3<br />
+
[[3cv9]], [[2zbz]] - SgP450105A1 (mutant)+vitamin D3<br />
-
[[2zbx]] - SgCYP105A1+imidazole<br />
+
[[2zbx]] - SgP450105A1+imidazole<br />
-
[[3dam]], [[3dan]], [[3dbm]] – CYP74A2 – ''Parthenium argentatum''<br />
+
[[3dam]], [[3dan]], [[3dbm]] – P45074A2 – ''Parthenium argentatum''<br />
-
[[2rch]], [[3dsi]] – AtCYP74A+13(S)-HOD – ''Arabidopsis thaliana''<br />
+
[[2rch]], [[3dsi]] – AtP45074A+13(S)-HOD – ''Arabidopsis thaliana''<br />
-
[[3dsj]] - AtCYP74A (mutant)+13(S)-HOD<br />
+
[[3dsj]] - AtP45074A (mutant)+13(S)-HOD<br />
-
[[2rcl]] - AtCYP74A+vernolic acid<br />
+
[[2rcl]] - AtP45074A+vernolic acid<br />
-
[[3dsk]] - AtCYP74A (mutant)+ vernolic acid<br />
+
[[3dsk]] - AtP45074A (mutant)+ vernolic acid<br />
-
[[2rcm]], [[3cli]] - AtCYP74A<br />
+
[[2rcm]], [[3cli]] - AtP45074A<br />
-
[[2rfb]] – PtCYP – ''Picrophilus torridus''<br />
+
[[2rfb]] – PtP450 – ''Picrophilus torridus''<br />
-
[[2rfc]] – PtCYP+phenylimidazole
+
[[2rfc]] – PtP450+phenylimidazole
-
[[2nz5]], [[2nza]], [[2dkk]] – ScCYP158A1 – ''Streptomyces coelicolor''<br />
+
[[2nz5]], [[2nza]], [[2dkk]] – ScP450158A1 – ''Streptomyces coelicolor''<br />
-
[[1gwi]] - ScCYP154C1<br />
+
[[1gwi]] - ScP450154C1<br />
-
[[1wiy]] – TtCYP – ''Thermus thermophilus''<br />
+
[[1wiy]] – TtP450 – ''Thermus thermophilus''<br />
-
[[1n97]] – TtCYP175A1
+
[[1n97]] – TtP450175A1<br />
 +
[[3lxh]], [[3lxi]] – NaP240101D1 – ''Novosphingobium aromaticivorans''<br />
 +
[[3nv5]], [[3nv6]] - NaP240101D2<br />
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 10:31, 27 January 2011

Image:2f9q.png
Crystal Structure of Cytochrome P450 2f9q

Template:STRUCTURE 2f9q

Cytochrome P450 (P450) catalyzes the oxidation of organic substances like lipids. catalyzes the oxidation of organic substances like lipids. The P450 contains a heme cofactor. The protein is numbered by its gene. P450cam, also known as camphor 5-monooxygenase, catalyzes the hydroxylation of camphor. P450nor is a Nitric Oxide Reductase P450. P450epoK converts epothilone D to epothilone B. P450cin monooxygenates 1,8-cineole which is similar to camphor. The images at the left and at the right correspond to one representative P450, i.e. the crystal structure of human P4502 (2f9q).

Contents

3D Structures of Cytochrome P450

human P4501 family

2hi4 – hP4501A2+naphthoflavone - human
3pm0 - hP4501B1+naphthoflavone

human P4502 family

3gph, 3koh, 3lc4 – hP4502E1 fragment +imidazole derivative
3e6i – hP4502E1 fragment+indazole
3ebs – hP4502A6 (mutant)+phenacetin
2fdu, 2fdv, 2fdw, 2fdy - hP4502A6+pyridine derivative
1z10 - hP4502A6 catalytic domain+coumarin
3e4e – hP4502E1 fragment+methylpyrazole
3czh, 3dl9, 3c6g – hP4502R1+vitamin D
2nnh – hP4502C8+retinoic acid
2nni - hP4502C8+montelukast
2nnj - hP4502C8+felodipine
1pq2 - hP4502C8
1og2, 1og5 – hP4502C9 (mutant)
1r9o – hP4502C9 (mutant)+flurbiprofen
2pg5, 2pg6, 2pg7 – hP4502A6 (mutant)
2p85 – hP4502A13 (mutant)+indole
3ibd – hP4502B6 (mutant)+4-(4-chlorophenyl)imidazole
2f9q – hP4502D6
2z10 – hP4502A6+coumarin
1z11 - hP4502A6+methoxalen


human P4503 family

2v0m – hP4503A4+ketoconazole
2j0d - hP4503A4+erythromycin
3nxu - hP4503A4+ritonavir
1tqn, 1w0e, 1w0f, 1w0g – hP4503A4


human P4507 family

3dax – hP4507A1


human P45019 family

3eqm - hP45019A1+androstenedione


human P45046 family

2q9f – hP45046A1+cholesterol
2q9d, 2q9g - hP45046A1
2vn0 – hP450105A1+troglitazone
2zby - hP450105A1 (mutant)


P450 from Mycobacterium tuberculosis

2vku, 1h5z – MtP45051 - Mycobacterium tuberculosis
2ci0, 2cib, 1u13 - MtP45051 (mutant)
1x8v - MtP45051 (mutant)+estriol
1ea1 - MtP45051 (mutant)+ fluconazole
1e9x - MtP45051 (mutant)+ phenylimidazole
3cxv, 3cxx, 3cxy, 3cxz, 3cy0, 3cy1 - MtP450121 (mutant)
3g5f, 3g5h, 2ij5, 1n40 – MtP450121
2ij7 - MtP450121+fluconazole
1n4g - MtP450121+iodopyrazole
3ivi, 3iw0 – MtP450125
3iw1 - MtP450125+androstenedione
3iw2 - MtP450125+econazole
2uvn - MtP450130+econazole
2wgy – MtP450130 (mutant)
2w09, 2w0b, 2w0a - MtP450130 (mutant)+pyridine inhibitor
2uuq – MtP450130


P450cam

2qbl, 2qbm, 2qbn, 2gqx, 2gr6, 2frz, 2h7s, 6cp4, 2cp4, 3cp4, 4cp4, 1c8j, 1geb, 2a1o – PpP450cam(mutant) – Pseudomona putida
1dz4, 1dz8, 1dz6, 1dz9, 5cp4, 1phc, 2cpp, 1yrc, 1yrd, 3l61, 3l62, 3l63 - PpP450cam
2qbo - PpP450cam (mutant)+cyanide
1qmq - PpP450cam (mutant)+Ru substrate
2h7q - PpP450cam+imidazole
1cp4 - PpP450cam+benzene
1akd, 1iwi, 1noo, 7cpp, 8cpp, 2zwt, 2zwu - PpP450cam+1S-camphor derivative
1iwj, 1iwk, 2zuh, 2zui, 2zuj, 3fwf, 3fwg, 3fwi, 3fwj - PpP450cam (mutant)+1Scamphor
2fe6, 2fer, 2feu - PpP450cam+Mn protoporphyrin IX
1uyu - PpP450cam+ Xe
1o76 - PpP450cam+cyanide
4cpp - PpP450cam+adamantine
5cpp - PpP450cam+adamantanone
6cpp - PpP450cam+camphene
1p2y, 1p7r - PpP450cam+nicotine
1re9, 1rf9 - PpP450cam +fluorescent probe
2z97, 2zaw, 2zax - PpP450cam+methyl depropionated hemin
3cpp - PpP450cam+CO
1pha, 1phb, 1phd, 1phe, 1phf, 1phg - PpP450cam+imidazole derivative
1gek, 1gem - PpP450cam+N-butyl-isocyanide
1lwl - PpP450cam+fluorescent probe
2h7r - PpP450cam (mutant)+imidazole
1k2o - PpP450cam (mutant)+pyridine derivative
1gjm - PpP450cam (mutant)+sulphydryl reagent
2a1m, 2a1n, 2a10 - PpP450cam (mutant)+ferrous dioxygen
1t85, 1t86, 1t87, 1t88 - PpP450cam (mutant)+ferrous CO
1j51 - PpP450cam (mutant)+trichlorobenzene
1mpw - PpP450cam (mutant)+trimethylbicycloheptene
3oia, 3ol5, 3p6m, 3p6n, 3p6o, 3p6p, 3poq, 3por, 3pos, 3pot, 3pou, 3pov, 3pow, 3pox - PpP450cam (mutant)+substrate analog


P450nor

1cl6, 1rom – FoP450nor - Fusarium oxysporum
2rom - FoP450nor+CO
1cmj, 1cmn, 1ehg - FoP450nor (mutant)
1xqd – FoP450nor+pyridinealdehyde adenine
1jfb, 1jfc, 1ged, 1ehe - FoP450nor
1gej, 1gei - FoP450nor+N-butyl-isocyanide
1ulw - FoP450nor (mutant)

P450epoK

1pfk – P450epoK+epothilone D – Sorangium cellulosum

P450cin

3bdz, 3be0 – P450cin – Citrobacter braakii

rabbit P450

2bdm – rP4502B4 – rabbit
1po5, 3mvr - rP4502B4 (mutant)
1suo - rP4502B4 (mutant)+imidazole
3kw4, 3me6 - rP4502B4 (mutant)+anti-platelet drug
1dt6 - rP4502C5 (mutant)
1nr6 – rP4502C5+diclofenac
1n6b - rP4502C5+sulfaphenazole


Other CYPs

1ued – AoP450 oxyC – Amycolatopsis orientalis
1lfk, 1lg9, 1lgf - AoP450 oxyB
1q5d – ScP450EPOK+epothilone – Sorangium cellulosum
1q5e - ScP450EPOK
1io8 – SsP450119 (mutant) – Sulfolobus solfataricus
1io9, 1io7, 1f4u - SsP450119
1f4t - SsP450119+ phenylimidazole
1cpt – P450108 – Pseudomonas sp.
2uwh - BmP450102+palmitic acid
3ekb, 3ekd, 3ekf, 2ij3, 2ij4 - BmP450102 heme domain (mutant)
2ij2, 2hpd - BmP450102 heme domain
3ben - BmP450102 + imidazole derivative
2j1m, 2j4s - BmP450102+DMSO
1bvy, 1bu7 – BmP450102A1 FMN domain
1fag – BmP450102A1+ palmitic acid
1fah – BmP450102A1 (mutant)
2bmh - BmP450102A1
3aba – SaP450105P1+filipin I – Streptomyces avermitilis
3abb – SaP450105D6
3e5j, 3e5l - SaP450105P1 (mutant)
3e5k - SaP450105P1 (mutant)+4-phenylimidazole
2whw, 2wi9, 2vz7 – SvP450107L1 (mutant) – Streptomyces venezuelae
2vzm – SvP450107L1 (mutant)+narbomycin
2c7x - SvP450107L1+narbomycin
2cd8, 2ca0, 2c6h – SvP450107L1+YC-17
2bvj - SvP450107L1
2zqj – BsP450152A1 – Bacillus subtilis
2zqx - BsP450152A1+heptanoic acid
3nc3, 3nc5, 3nc6, 3nc7 - BsP450134A1 (mutant)
1izo – BsP450 BS beta+ palmitoleic acid
1jin, 1jip - SeP450107A1+ ketoconazole - Saccharopolyspora erythraea
1jio, 1oxa - SeP450107A1+6DEB
1eup – SeP450107A1+androstendione
1egy - SeP450107A1+aminophenanthrene
2jjn, 2jjo - SeP450113A1 (mutant)
2jjp - SeP450113A1 (mutant)+ketoconazole
2vrv - SeP450113A1 (mutant)+clotrimazole
3a1l – SsP450245A1+dichlorochrompyrrolic acid – Streptomyces sp.
2z3t - SsP450245A1
2z3u - SsP450245A1+chromopyrrolic acid
3g5n, 3g93 – rCYP2B4 (mutant)+1-biphenyl-4-methyl-1H-imidazole – rabbit
2q6n – rP4502B4 (mutant)+chlorophenyl-imidazole
3cv8 – SgP450105A1 (mutant) – Streptomyces griseolus
3cv9, 2zbz - SgP450105A1 (mutant)+vitamin D3
2zbx - SgP450105A1+imidazole
3dam, 3dan, 3dbm – P45074A2 – Parthenium argentatum
2rch, 3dsi – AtP45074A+13(S)-HOD – Arabidopsis thaliana
3dsj - AtP45074A (mutant)+13(S)-HOD
2rcl - AtP45074A+vernolic acid
3dsk - AtP45074A (mutant)+ vernolic acid
2rcm, 3cli - AtP45074A
2rfb – PtP450 – Picrophilus torridus
2rfc – PtP450+phenylimidazole 2nz5, 2nza, 2dkk – ScP450158A1 – Streptomyces coelicolor
1gwi - ScP450154C1
1wiy – TtP450 – Thermus thermophilus
1n97 – TtP450175A1
3lxh, 3lxi – NaP240101D1 – Novosphingobium aromaticivorans
3nv5, 3nv6 - NaP240101D2

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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