2q1z
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(New page: 200px<br /><applet load="2q1z" size="350" color="white" frame="true" align="right" spinBox="true" caption="2q1z, resolution 2.40Å" /> '''Crystal Structure of...)
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Revision as of 11:35, 23 January 2008
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Crystal Structure of Rhodobacter sphaeroides SigE in complex with the anti-sigma ChrR
Overview
A transcriptional response to singlet oxygen in Rhodobacter sphaeroides is, controlled by the group IV sigma factor sigma(E) and its cognate, anti-sigma ChrR. Crystal structures of the sigma(E)/ChrR complex reveal a, modular, two-domain architecture for ChrR. The ChrR N-terminal anti-sigma, domain (ASD) binds a Zn(2+) ion, contacts sigma(E), and is sufficient to, inhibit sigma(E)-dependent transcription. The ChrR C-terminal domain, adopts a cupin fold, can coordinate an additional Zn(2+), and is required, for the transcriptional response to singlet oxygen. Structure-based, sequence analyses predict that the ASD defines a common structural fold, among predicted group IV anti-sigmas. These ASDs are fused to diverse, C-terminal domains that are likely involved in responding to specific, environmental signals that control the activity of their cognate sigma, factor.
About this Structure
2Q1Z is a Protein complex structure of sequences from Rhodobacter sphaeroides with as ligand. Full crystallographic information is available from OCA.
Reference
A conserved structural module regulates transcriptional responses to diverse stress signals in bacteria., Campbell EA, Greenwell R, Anthony JR, Wang S, Lim L, Das K, Sofia HJ, Donohue TJ, Darst SA, Mol Cell. 2007 Sep 7;27(5):793-805. PMID:17803943
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