1aii
From Proteopedia
(New page: 200px<br /> <applet load="1aii" size="450" color="white" frame="true" align="right" spinBox="true" caption="1aii, resolution 1.95Å" /> '''ANNEXIN III'''<br /...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1AII is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with CA, SO4 and ETA as [[http://en.wikipedia.org/wiki/ligands ligands]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1AII OCA]]. | + | 1AII is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with CA, SO4 and ETA as [[http://en.wikipedia.org/wiki/ligands ligands]]. Structure known Active Sites: CAD, CBD and CCD. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1AII OCA]]. |
==Reference== | ==Reference== | ||
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[[Category: phospholipase a2 inhibitor]] | [[Category: phospholipase a2 inhibitor]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 11:32:49 2007'' |
Revision as of 09:28, 30 October 2007
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ANNEXIN III
Overview
Annexin III, a putative inositol (1,2)-phosphohydrolase, was, co-crystallized with inositol 2-phosphate, the inhibitor of the reaction, and its structure was solved to 1.95 A resolution. No enzyme active site, was observed in the structure. Assays for enzymatic activity were also, negative. Search for annexin III-inositol phosphate interactions using the, BIAcoreTM system revealed an affinity for inositol cyclic (1,2)-phosphate, suggesting annexin III may sequester the molecule in the cell. The, BIAcoreTM system used with different phospholipids showed that annexin III, displays specificity for phosphatidylethanolamine, but not for, phosphatidylinositols. Interestingly, a molecule of ethanolamine was found, bound to the protein in the crystal structure. Coupled with the fact that, this is ... [(full description)]
About this Structure
1AII is a [Single protein] structure of sequence from [Homo sapiens] with CA, SO4 and ETA as [ligands]. Structure known Active Sites: CAD, CBD and CCD. Full crystallographic information is available from [OCA].
Reference
Can enzymatic activity, or otherwise, be inferred from structural studies of annexin III?, Perron B, Lewit-Bentley A, Geny B, Russo-Marie F, J Biol Chem. 1997 Apr 25;272(17):11321-6. PMID:9111038
Page seeded by OCA on Tue Oct 30 11:32:49 2007
