2uzg
From Proteopedia
(New page: 200px<br /> <applet load="2uzg" size="450" color="white" frame="true" align="right" spinBox="true" caption="2uzg" /> '''ZF-UBP DOMAIN OF VDU1'''<br /> ==Overview=...) |
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| - | [[Image:2uzg. | + | [[Image:2uzg.jpg|left|200px]]<br /><applet load="2uzg" size="350" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="2uzg" size=" | + | |
caption="2uzg" /> | caption="2uzg" /> | ||
'''ZF-UBP DOMAIN OF VDU1'''<br /> | '''ZF-UBP DOMAIN OF VDU1'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2UZG is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with ZN as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | + | 2UZG is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=ZN:'>ZN</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UZG OCA]. |
==Reference== | ==Reference== | ||
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[[Category: zinc-finger]] | [[Category: zinc-finger]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 23 13:37:51 2008'' |
Revision as of 11:37, 23 January 2008
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ZF-UBP DOMAIN OF VDU1
Overview
USP33/VDU1 is a deubiquitinating enzyme that binds to the von, Hippel-Lindau tumor suppressor protein. It also regulates thyroid hormone, activation by deubiquitinating type 2 iodothyronine deiodinase. USP33/VDU1, contains a ZF UBP domain, a protein module found in many proteins in the, ubiquitin-proteasome system. Several ZF UBP domains have been shown to, bind ubiquitin, and a structure of a complex of the ZF UBP domain of, isoT/USP5 and ubiquitin is available. In the present work, the solution, structure of the ZF UBP domain of USP33/VDU1 has been determined by NMR, spectroscopy. The structure differs from that of the USP5 domain, which, contains only one of the three Zn ions present in the USP33/VDU1, structure. The USP33/VDU1 ZnF UBP domain does not bind to ubiquitin.
About this Structure
2UZG is a Single protein structure of sequence from Homo sapiens with as ligand. Full crystallographic information is available from OCA.
Reference
The solution structure of the ZnF UBP domain of USP33/VDU1., Allen MD, Bycroft M, Protein Sci. 2007 Sep;16(9):2072-5. PMID:17766394
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