2phr

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Revision as of 11:43, 23 January 2008

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spinqualitylabelsall models 2phr, resolution 1.90Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

Pterocarpus angolensis lectin (PAL) in complex with Man-7D1

Overview

The crystal structure of Pterocarpus angolensis seed lectin is presented, in complex with a series of high mannose oligosaccharides ranging from, Man-5 to Man-9. Despite that several of the nine mannose residues of Man-9, have the potential to bind in the monosaccharide binding site, all, oligomannoses are bound in the same unique way employing the, tetrasaccharide sequence, Manalpha(1-2)Manalpha(1-6)[Manalpha(1-3)]Manalpha(1-. ITC titration, experiments using Man-5, Man-9 and the Man-9-containing glycoprotein, soybean agglutinin as ligands confirm the monovalence of Man-9 and show a, four times higher affinity for Man-9 when it is presented to Pterocarpus, angolensis seed lectin in a glycoprotein context.

About this Structure

2PHR is a Single protein structure of sequence from Pterocarpus angolensis with and as ligands. Full crystallographic information is available from OCA.

Reference

How a Plant Lectin Recognizes High Mannose oligosaccharides., Garcia-Pino A, Buts L, Wyns L, Imberty A, Loris R, Plant Physiol. 2007 Jun 7;. PMID:17556509

Page seeded by OCA on Wed Jan 23 13:43:29 2008