2ith
From Proteopedia
(New page: 200px<br /><applet load="2ith" size="450" color="white" frame="true" align="right" spinBox="true" caption="2ith" /> '''NMR Structure of Haloferax volcanii DHFR'''<...) |
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'''NMR Structure of Haloferax volcanii DHFR'''<br /> | '''NMR Structure of Haloferax volcanii DHFR'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2ITH is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Haloferax_volcanii Haloferax volcanii]. Active as [http://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3] Full crystallographic information is available from [http:// | + | 2ITH is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Haloferax_volcanii Haloferax volcanii]. Active as [http://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ITH OCA]. |
==Reference== | ==Reference== | ||
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[[Category: oxidoreductase]] | [[Category: oxidoreductase]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 23 13:45:49 2008'' |
Revision as of 11:45, 23 January 2008
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NMR Structure of Haloferax volcanii DHFR
Overview
Proteins from halophiles have adapted to challenging environmental, conditions and require salt for their structure and function. How, halophilic proteins adapted to a hypersaline environment is still an, intriguing question. It is important to mimic the physiological conditions, of the archae extreme halophiles when characterizing their enzymes, including structural characterization. The NMR derived structure of, Haloferax volcanii dihydrofolate reductase in 3.5 M NaCl is presented, and, represents the first high salt structure calculated using NMR data., Structure calculations show that this protein has a solution structure, which is similar to the previously determined crystal structure with a, difference at the N terminus of beta3 and the type of beta-turn connection, beta7 and beta8.
About this Structure
2ITH is a Single protein structure of sequence from Haloferax volcanii. Active as Dihydrofolate reductase, with EC number 1.5.1.3 Full crystallographic information is available from OCA.
Reference
Structure in an extreme environment: NMR at high salt., Binbuga B, Boroujerdi AF, Young JK, Protein Sci. 2007 Aug;16(8):1783-7. PMID:17656587
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