TonB

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TonB is involved in the uptake of iron as a component of the TonB/ExbB/ExbD complex of the [[Ton]] system.
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TonB is involved in the uptake of iron as a component of the TonB/[[ExbB]]/[[ExbD]] complex of the [[Ton]] system.
==Structure==
==Structure==
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TonB and ExbD bind to ExbB in a protein complex that prevents the degradation of the TonB protein. TonB and ExbD are anchored to the cytoplasmic membrane via their N-terminal hydrophobic sequences, with the rest of the protein complex extending into the periplasmic space, allowing for interaction with outer membrane proteins.<ref name='Kampfenkel'>PMID: 8449962</ref>
==Function==
==Function==
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The activity of TonB is determined by the presence of ExbB and ExbD. <ref name='Kampfenkel'>PMID: 8449962</ref>
==Regulation==
==Regulation==

Revision as of 11:08, 14 February 2011

TonB is involved in the uptake of iron as a component of the TonB/ExbB/ExbD complex of the Ton system.


Contents

Structure

TonB and ExbD bind to ExbB in a protein complex that prevents the degradation of the TonB protein. TonB and ExbD are anchored to the cytoplasmic membrane via their N-terminal hydrophobic sequences, with the rest of the protein complex extending into the periplasmic space, allowing for interaction with outer membrane proteins.[1]

Function

The activity of TonB is determined by the presence of ExbB and ExbD. [1]

Regulation

References

  1. 1.0 1.1 Kampfenkel K, Braun V. Topology of the ExbB protein in the cytoplasmic membrane of Escherichia coli. J Biol Chem. 1993 Mar 15;268(8):6050-7. PMID:8449962

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Laura McCauley

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