2z3r
From Proteopedia
(New page: 200px<br /> <applet load="2z3r" size="450" color="white" frame="true" align="right" spinBox="true" caption="2z3r, resolution 2.00Å" /> '''Crystal structure o...) |
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| - | [[Image:2z3r.gif|left|200px]]<br /> | + | [[Image:2z3r.gif|left|200px]]<br /><applet load="2z3r" size="350" color="white" frame="true" align="right" spinBox="true" |
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caption="2z3r, resolution 2.00Å" /> | caption="2z3r, resolution 2.00Å" /> | ||
'''Crystal structure of the IL-15/IL-15Ra complex'''<br /> | '''Crystal structure of the IL-15/IL-15Ra complex'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2Z3R is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with GOL as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | + | 2Z3R is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=GOL:'>GOL</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z3R OCA]. |
==Reference== | ==Reference== | ||
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[[Category: protein-protein complex]] | [[Category: protein-protein complex]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 23 13:48:21 2008'' |
Revision as of 11:48, 23 January 2008
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Crystal structure of the IL-15/IL-15Ra complex
Overview
Interleukin 15 (IL-15) and IL-2, which promote the survival of memory, CD8(+) T cells and regulatory T cells, respectively, bind receptor, complexes that share beta- and gamma-signaling subunits. Receptor, specificity is provided by unique, nonsignaling alpha-subunits. Whereas, IL-2 receptor-alpha (IL-2Ralpha) is expressed together in cis with the, beta- and gamma-subunits on T cells and B cells, IL-15Ralpha is expressed, in trans on antigen-presenting cells. Here we present a 1.85-A crystal, structure of the human IL-15-IL-15Ralpha complex. The structure provides, insight into the molecular basis of the specificity of cytokine, recognition and emphasizes the importance of water in generating this very, high-affinity complex. Despite very low IL-15-IL-2 sequence homology and, distinct receptor architecture, the topologies of the IL-15-IL-15Ralpha, and IL-2-IL-2Ralpha complexes are very similar. Our data raise the, possibility that IL-2, like IL-15, might be capable of being presented in, trans in the context of its unique receptor alpha-chain.
About this Structure
2Z3R is a Protein complex structure of sequences from Homo sapiens with as ligand. Full crystallographic information is available from OCA.
Reference
Crystal structure of the IL-15-IL-15Ralpha complex, a cytokine-receptor unit presented in trans., Chirifu M, Hayashi C, Nakamura T, Toma S, Shuto T, Kai H, Yamagata Y, Davis SJ, Ikemizu S, Nat Immunol. 2007 Sep;8(9):1001-7. Epub 2007 Jul 22. PMID:17643103
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