3me6
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | + | [[Image:3me6.png|left|200px]] | |
| - | [[Image:3me6. | + | |
<!-- | <!-- | ||
| Line 12: | Line 11: | ||
===Crystal structure of cytochrome 2B4 in complex with the anti-platelet drug clopidogrel=== | ===Crystal structure of cytochrome 2B4 in complex with the anti-platelet drug clopidogrel=== | ||
| + | |||
| + | <!-- | ||
| + | The line below this paragraph, {{ABSTRACT_PUBMED_20815363}}, adds the Publication Abstract to the page | ||
| + | (as it appears on PubMed at http://www.pubmed.gov), where 20815363 is the PubMed ID number. | ||
| + | --> | ||
| + | {{ABSTRACT_PUBMED_20815363}} | ||
==About this Structure== | ==About this Structure== | ||
| - | + | [[3me6]] is a 4 chain structure of [[Cytochrome P450]] with sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ME6 OCA]. | |
| + | |||
| + | ==See Also== | ||
| + | *[[Cytochrome P450]] | ||
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID:16373351</ref><ref group="xtra">PMID:15100217</ref><ref group="xtra">PMID:14563924</ref><ref group="xtra">PMID:17887776</ref><ref group="xtra">PMID:19397311</ref><references group="xtra"/> | + | <ref group="xtra">PMID:20815363</ref><ref group="xtra">PMID:16373351</ref><ref group="xtra">PMID:15100217</ref><ref group="xtra">PMID:14563924</ref><ref group="xtra">PMID:17887776</ref><ref group="xtra">PMID:19397311</ref><references group="xtra"/> |
[[Category: Oryctolagus cuniculus]] | [[Category: Oryctolagus cuniculus]] | ||
[[Category: Unspecific monooxygenase]] | [[Category: Unspecific monooxygenase]] | ||
| Line 28: | Line 36: | ||
[[Category: Talakad, J C.]] | [[Category: Talakad, J C.]] | ||
[[Category: Zhang, Q.]] | [[Category: Zhang, Q.]] | ||
| - | [[Category: Cyp 2b4]] | ||
| - | [[Category: Cyp lm2]] | ||
| - | [[Category: Cytochrome p450 2b4]] | ||
| - | [[Category: Membrane protein]] | ||
| - | [[Category: Monooxygenase]] | ||
| - | [[Category: Oxidoreductase]] | ||
| - | [[Category: P450]] | ||
| - | |||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 15 10:50:03 2010'' | ||
Revision as of 05:03, 16 February 2011
Contents |
Crystal structure of cytochrome 2B4 in complex with the anti-platelet drug clopidogrel
Template:ABSTRACT PUBMED 20815363
About this Structure
3me6 is a 4 chain structure of Cytochrome P450 with sequence from Oryctolagus cuniculus. Full crystallographic information is available from OCA.
See Also
Reference
- Gay SC, Roberts AG, Maekawa K, Talakad JC, Hong WX, Zhang Q, Stout CD, Halpert JR. Structures of cytochrome P450 2B4 complexed with the antiplatelet drugs ticlopidine and clopidogrel . Biochemistry. 2010 Oct 12;49(40):8709-20. Epub 2010 Sep 15. PMID:20815363 doi:10.1021/bi100914z
- Zhao Y, White MA, Muralidhara BK, Sun L, Halpert JR, Stout CD. Structure of microsomal cytochrome P450 2B4 complexed with the antifungal drug bifonazole: insight into P450 conformational plasticity and membrane interaction. J Biol Chem. 2006 Mar 3;281(9):5973-81. Epub 2005 Dec 21. PMID:16373351 doi:10.1074/jbc.M511464200
- Scott EE, White MA, He YA, Johnson EF, Stout CD, Halpert JR. Structure of mammalian cytochrome P450 2B4 complexed with 4-(4-chlorophenyl)imidazole at 1.9-A resolution: insight into the range of P450 conformations and the coordination of redox partner binding. J Biol Chem. 2004 Jun 25;279(26):27294-301. Epub 2004 Apr 20. PMID:15100217 doi:10.1074/jbc.M403349200
- Scott EE, He YA, Wester MR, White MA, Chin CC, Halpert JR, Johnson EF, Stout CD. An open conformation of mammalian cytochrome P450 2B4 at 1.6-A resolution. Proc Natl Acad Sci U S A. 2003 Nov 11;100(23):13196-201. Epub 2003 Oct 16. PMID:14563924 doi:http://dx.doi.org/10.1073/pnas.2133986100
- Zhao Y, Sun L, Muralidhara BK, Kumar S, White MA, Stout CD, Halpert JR. Structural and thermodynamic consequences of 1-(4-chlorophenyl)imidazole binding to cytochrome P450 2B4. Biochemistry. 2007 Oct 16;46(41):11559-67. Epub 2007 Sep 22. PMID:17887776 doi:http://dx.doi.org/10.1021/bi7011614
- Gay SC, Sun L, Maekawa K, Halpert JR, Stout CD. Crystal structures of cytochrome P450 2B4 in complex with the inhibitor 1-biphenyl-4-methyl-1Himidazole: ligand induced structural response through -helical repositioning. Biochemistry. 2009 Apr 27. PMID:19397311 doi:10.1021/bi9003765
