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Stromal Derived Factor 1
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{{STRUCTURE_2kec| right| PDB=2kec | SCENE= |CAPTION=Stromal Derived Factor 1α, [[2kec]] }} | {{STRUCTURE_2kec| right| PDB=2kec | SCENE= |CAPTION=Stromal Derived Factor 1α, [[2kec]] }} | ||
| - | [[Stromal Derived Factor 1]] (SDF-1α) or CXCL12 is a small cytokine from the chemokine family. | + | [[Stromal Derived Factor 1]] (SDF-1α) or CXCL12 is a small cytokine from the chemokine family. It is natural ligand of [[CXC chemokine receptor type 4|CXCR4]] It has a role in angiogenesis, tumor metastasis and the migration of cells from the liver to the bone marrow during embryogenesis. The images on the left and right correspond to one representative SDF-1α structure, ''i.e.'' the human SDF-1α ([[2kec]]). |
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Revision as of 08:52, 23 February 2011
Stromal Derived Factor 1 (SDF-1α) or CXCL12 is a small cytokine from the chemokine family. It is natural ligand of CXCR4 It has a role in angiogenesis, tumor metastasis and the migration of cells from the liver to the bone marrow during embryogenesis. The images on the left and right correspond to one representative SDF-1α structure, i.e. the human SDF-1α (2kec).
3D Structures of Stromal Derived Factor 1
2kec, 2ked, 2kee, 2sdf, 1sdf - hSDF1α – NMR - human
2k0l, 2k01 – hSDF1α (mutant) – NMR
1a15 - hSDF1α (mutant)
2nwg - hSDF1α+heparin
2j7z - hSDF1α residues 22-89
2k03, 2k04, 2k05 - hSDF1α (mutant)+ hCXCR4 N-terminal (mutant)
