1go8
From Proteopedia
(New page: 200px<br /> <applet load="1go8" size="450" color="white" frame="true" align="right" spinBox="true" caption="1go8, resolution 2.00Å" /> '''THE METZINCIN'S MET...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1GO8 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Erwinia_chrysanthemi Erwinia chrysanthemi]] with CA, ZN and PO4 as [[http://en.wikipedia.org/wiki/ligands ligands]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1GO8 OCA]]. | + | 1GO8 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Erwinia_chrysanthemi Erwinia chrysanthemi]] with CA, ZN and PO4 as [[http://en.wikipedia.org/wiki/ligands ligands]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1GO8 OCA]]. |
==Reference== | ==Reference== | ||
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[[Category: protease]] | [[Category: protease]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 11:37:25 2007'' |
Revision as of 09:32, 30 October 2007
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THE METZINCIN'S METHIONINE: PRTC M226L MUTANT
Overview
Serralysins are a family of metalloproteases secreted by Gram-negative, bacteria into the medium in the form of inactive zymogens. Usually, all, serralysin secretors have on the same operon a gene coding for a, periplasmic 10-kDa protein, which is an inhibitor of the secreted, protease. The recent characterization of the inhibitor of the alkaline, protease from Pseudomonas aeruginosa revealed a surprisingly low, dissociation constant of 4 pm, contrary to earlier studies on homologous, systems, where inhibition constants in the microm range were reported. To, approach a more accurate understanding, the crystal structure of the, complex between inhibitor and protease from P. aeruginosa was determined, at 1.74 A resolution and refined to R(free) = 0.204. The structure, reported here shows ... [(full description)]
About this Structure
1GO8 is a [Single protein] structure of sequence from [Erwinia chrysanthemi] with CA, ZN and PO4 as [ligands]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
Crystal structure of a complex between Pseudomonas aeruginosa alkaline protease and its cognate inhibitor: inhibition by a zinc-NH2 coordinative bond., Hege T, Feltzer RE, Gray RD, Baumann U, J Biol Chem. 2001 Sep 14;276(37):35087-92. Epub 2001 Jul 9. PMID:11445573
Page seeded by OCA on Tue Oct 30 11:37:25 2007
Categories: Erwinia chrysanthemi | Single protein | Baumann, U. | CA | PO4 | ZN | Hydrolase | Metalloprotease | Protease
