Colicin M
From Proteopedia
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{{STRUCTURE_2xmx | PDB=2xmx | SCENE= Colicin_M/Colm/1 }} | {{STRUCTURE_2xmx | PDB=2xmx | SCENE= Colicin_M/Colm/1 }} | ||
| - | Colicin M is a type of [[Colicin]], a bacteriocin made by ''E. coli'' which acts against other nearby ''E. coli'' to kill them by inhibiting synthesis of peptidoglycan - murein, preventing synthesis of the cell wall and ultimately leading to cell lysis. | + | Colicin M is a type of [[Colicin]], a bacteriocin made by ''E. coli'' which acts against other nearby ''E. coli'' to kill them by inhibiting synthesis of peptidoglycan - murein, preventing synthesis of the cell wall and ultimately leading to cell lysis. <scene name='Colicin_M/Colmsingle/1'>Monomer</scene> of Colicin M. |
Revision as of 14:44, 25 February 2011
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| 2xmx, resolution 1.67Å () | |||||||
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| Ligands: | , | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Colicin M is a type of Colicin, a bacteriocin made by E. coli which acts against other nearby E. coli to kill them by inhibiting synthesis of peptidoglycan - murein, preventing synthesis of the cell wall and ultimately leading to cell lysis. of Colicin M.
Contents |
Synthesis and release
Mechanism of uptake
Killing Activities
ColM shows enzymatic properties of degradation of lipid I and lipid II peptidoglycan intermediates. The cleavage occurs between the lipid moiety and the pyrophosphoryl groups. This then leads to the arrest of peptidoglycan polymerisation[1], rather than the direct degradation of the peptidoglycan[2].
References
- ↑ El Ghachi M, Bouhss A, Barreteau H, Touze T, Auger G, Blanot D, Mengin-Lecreulx D. Colicin M exerts its bacteriolytic effect via enzymatic degradation of undecaprenyl phosphate-linked peptidoglycan precursors. J Biol Chem. 2006 Aug 11;281(32):22761-72. Epub 2006 Jun 15. PMID:16777846 doi:10.1074/jbc.M602834200
- ↑ Schaller K, Dreher R, Braun V. Structural and functional properties of colicin M. J Bacteriol. 1981 Apr;146(1):54-63. PMID:7012126
