TonB
From Proteopedia
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TonB is involved in the uptake of iron as a component of the TonB/[[ExbB]]/[[ExbD]] complex of the [[Ton]] system. | TonB is involved in the uptake of iron as a component of the TonB/[[ExbB]]/[[ExbD]] complex of the [[Ton]] system. | ||
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TonB and ExbD bind to ExbB in a protein complex that prevents the degradation of the TonB protein. TonB and ExbD are anchored to the cytoplasmic membrane via their N-terminal hydrophobic sequences, with the rest of the protein complex extending into the periplasmic space, allowing for interaction with outer membrane proteins.<ref name='Kampfenkel'>PMID: 8449962</ref> | TonB and ExbD bind to ExbB in a protein complex that prevents the degradation of the TonB protein. TonB and ExbD are anchored to the cytoplasmic membrane via their N-terminal hydrophobic sequences, with the rest of the protein complex extending into the periplasmic space, allowing for interaction with outer membrane proteins.<ref name='Kampfenkel'>PMID: 8449962</ref> | ||
| - | {{STRUCTURE_1xx3 | PDB=1xx3 | SCENE= TonB/Ctdtonb/1 }} | ||
TonB complexes with BtuB in order to aid the transport of nutrients across the outer membrane by incorporating the proton-motive force into the outer membrane (see [[BtuB-TonB Complex]]).<ref name='Shultis'>PMID: 16741124</ref> | TonB complexes with BtuB in order to aid the transport of nutrients across the outer membrane by incorporating the proton-motive force into the outer membrane (see [[BtuB-TonB Complex]]).<ref name='Shultis'>PMID: 16741124</ref> | ||
Revision as of 15:18, 27 February 2011
TonB is involved in the uptake of iron as a component of the TonB/ExbB/ExbD complex of the Ton system.
Contents |
Structure
TonB and ExbD bind to ExbB in a protein complex that prevents the degradation of the TonB protein. TonB and ExbD are anchored to the cytoplasmic membrane via their N-terminal hydrophobic sequences, with the rest of the protein complex extending into the periplasmic space, allowing for interaction with outer membrane proteins.[1]
TonB complexes with BtuB in order to aid the transport of nutrients across the outer membrane by incorporating the proton-motive force into the outer membrane (see BtuB-TonB Complex).[2]
Function
The activity of TonB is determined by the presence of ExbB and ExbD. [1]
Regulation
References
- ↑ 1.0 1.1 Kampfenkel K, Braun V. Topology of the ExbB protein in the cytoplasmic membrane of Escherichia coli. J Biol Chem. 1993 Mar 15;268(8):6050-7. PMID:8449962
- ↑ Shultis DD, Purdy MD, Banchs CN, Wiener MC. Outer membrane active transport: structure of the BtuB:TonB complex. Science. 2006 Jun 2;312(5778):1396-9. PMID:16741124 doi:312/5778/1396
