2ntn
From Proteopedia
(New page: 200px<br /><applet load="2ntn" size="450" color="white" frame="true" align="right" spinBox="true" caption="2ntn, resolution 2.30Å" /> '''Crystal structure of...) |
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| - | [[Image:2ntn.gif|left|200px]]<br /><applet load="2ntn" size=" | + | [[Image:2ntn.gif|left|200px]]<br /><applet load="2ntn" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="2ntn, resolution 2.30Å" /> | caption="2ntn, resolution 2.30Å" /> | ||
'''Crystal structure of MabA-C60V/G139A/S144L'''<br /> | '''Crystal structure of MabA-C60V/G139A/S144L'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2NTN is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Active as [http://en.wikipedia.org/wiki/3-oxoacyl-[acyl-carrier-protein]_reductase 3-oxoacyl-[acyl-carrier-protein] reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.100 1.1.1.100] Full crystallographic information is available from [http:// | + | 2NTN is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Active as [http://en.wikipedia.org/wiki/3-oxoacyl-[acyl-carrier-protein]_reductase 3-oxoacyl-[acyl-carrier-protein] reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.100 1.1.1.100] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NTN OCA]. |
==Reference== | ==Reference== | ||
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[[Category: sdr]] | [[Category: sdr]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 23 14:07:09 2008'' |
Revision as of 12:07, 23 January 2008
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Crystal structure of MabA-C60V/G139A/S144L
Overview
The MabA protein from Mycobacterium tuberculosis is a validated drug, target. Previous structural studies of this protein showed dynamic, behaviour in the catalytic site and described motion between an open, ;active' holo form (with NADP) and a closed ;inactive' apo form (without, NADP). Here, a mutation (G139A) is reported that leads to complete protein, inactivation and freezes the catalytic site into its closed form, even in, the presence of the cofactor. This observation suggests a new way to, develop anti-MabA drugs via protein stabilization of the ;inactive' form.
About this Structure
2NTN is a Single protein structure of sequence from Mycobacterium tuberculosis. Active as [acyl-carrier-protein_reductase 3-oxoacyl-[acyl-carrier-protein] reductase], with EC number 1.1.1.100 Full crystallographic information is available from OCA.
Reference
Lack of dynamics in the MabA active site kills the enzyme activity: practical consequences for drug-design studies., Poncet-Montange G, Ducasse-Cabanot S, Quemard A, Labesse G, Cohen-Gonsaud M, Acta Crystallogr D Biol Crystallogr. 2007 Aug;63(Pt 8):923-5. Epub 2007, Jul 17. PMID:17642518 [[Category: 3-oxoacyl-[acyl-carrier-protein] reductase]]
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