Sandbox Reserved 312

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{{STRUCTURE_2fbv| PDB=2fbv | SCENE= }}
{{STRUCTURE_2fbv| PDB=2fbv | SCENE= }}
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Werner (WRN) protein is one of the five human RecQDNA helicases, which unwinds DNA for translocation. WRN has a functional exonuclease domain.
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Werner (WRN) protein is one of the five human RecQDNA helicases, which unwinds DNA strands. WRN has a functional exonuclease domain .WRN protein protects human from cancer; as well as, premature aging.
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WRN protein protects human from cancer; as well as, premature aging. When the gene coding for WRN is mutated a autosomal recessive disorder causing rapid aging(osteoporosis, atherosclerosis and cancer). This is known as Werner syndrome which appears at puberty.
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=Function=
=Function=
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===Active Site===
===Active Site===
===Substrate-Binding Site===
===Substrate-Binding Site===
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=Clinical significance=
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When the gene coding for WRN is mutated a autosomal recessive disorder causing rapid aging(osteoporosis, atherosclerosis and cancer). This is known as Werner syndrome which appears at puberty.
=Reference=
=Reference=

Revision as of 06:23, 3 March 2011

This Sandbox is Reserved from January 10, 2010, through April 10, 2011 for use in BCMB 307-Proteins course taught by Andrea Gorrell at the University of Northern British Columbia, Prince George, BC, Canada.
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PDB ID 2fbv

Drag the structure with the mouse to rotate
2fbv, resolution 2.40Å ()
Ligands:
Gene: WRN, RECQ3, RECQL2 (Homo sapiens)
Related: 2fbt, 2fbx, 2fby, 2fc0
Resources: FirstGlance, OCA, RCSB, PDBsum
Coordinates: save as pdb, mmCIF, xml


Werner (WRN) protein is one of the five human RecQDNA helicases, which unwinds DNA strands. WRN has a functional exonuclease domain .WRN protein protects human from cancer; as well as, premature aging.


Contents

Function

Structure

WRN is a enzyme with both magnesium and ATP-dependent DNA-helicase activity with a 3'->5' exonuclease activity towards double-stranded DNA. Magnesium

Crystallization

Active Site

Substrate-Binding Site

Clinical significance

When the gene coding for WRN is mutated a autosomal recessive disorder causing rapid aging(osteoporosis, atherosclerosis and cancer). This is known as Werner syndrome which appears at puberty.

Reference

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