2pkx
From Proteopedia
(New page: 200px<br /><applet load="2pkx" size="450" color="white" frame="true" align="right" spinBox="true" caption="2pkx, resolution 2.54Å" /> '''E.coli response regu...) |
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| - | [[Image:2pkx.gif|left|200px]]<br /><applet load="2pkx" size=" | + | [[Image:2pkx.gif|left|200px]]<br /><applet load="2pkx" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="2pkx, resolution 2.54Å" /> | caption="2pkx, resolution 2.54Å" /> | ||
'''E.coli response regulator PhoP receiver domain'''<br /> | '''E.coli response regulator PhoP receiver domain'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2PKX is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. This structure superseeds the now removed PDB entry 2EU6. Full crystallographic information is available from [http:// | + | 2PKX is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. This structure superseeds the now removed PDB entry 2EU6. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PKX OCA]. |
==Reference== | ==Reference== | ||
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[[Category: virulence]] | [[Category: virulence]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 23 14:08:06 2008'' |
Revision as of 12:08, 23 January 2008
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E.coli response regulator PhoP receiver domain
Overview
The response regulator PhoP is part of the PhoQ/PhoP two-component system, involved in responses to depletion of extracellular Mg(2+). Here, we, report the crystal structures of the receiver domain of Escherichia coli, PhoP determined in the absence and presence of the phosphoryl analog, beryllofluoride. In the presence of beryllofluoride, the active receiver, domain forms a twofold symmetric dimer similar to that seen in structures, of other regulatory domains from the OmpR/PhoB family, providing further, evidence that members of this family utilize a common mode of dimerization, in the active state. In the absence of activating agents, the PhoP, receiver domain crystallizes with a similar structure, consistent with the, previous observation that high concentrations can promote an active state, of PhoP independent of phosphorylation.
About this Structure
2PKX is a Single protein structure of sequence from Escherichia coli. This structure superseeds the now removed PDB entry 2EU6. Full crystallographic information is available from OCA.
Reference
Crystal Structures of the Receiver Domain of the Response Regulator PhoP from Escherichia coli in the Absence and Presence of the Phosphoryl Analog Beryllofluoride., Bachhawat P, Stock AM, J Bacteriol. 2007 Aug;189(16):5987-95. Epub 2007 Jun 1. PMID:17545283
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